DBN1 Antikörper (AA 150-281)

Produktnummer ABIN6937083

Der Maus Monoklonal anti-DBN1 Antikörper wird verwendet zum Nachweis von DBN1 in Proben von Human. Er wurde validiert für WB und IHC.

Kurzübersicht für DBN1 Antikörper (AA 150-281) (ABIN6937083)

Target: DBN1 (Drebrin 1 (DBN1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser DBN1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Klon: DBN1-2879

Produktdetails anti-DBN1 Antikörper

Bindungsspezifität: AA 150-281

Verwendungszweck: Drebrin 1 (DBN1) Antibody

Spezifität: Drebrins (developmentally regulated brain proteins) are cytoplasmic proteins that bind F-actin in the brain and are involved in cell migration, extension of neuronal processes and plasticity of dendrites. There are three isoforms: two embryonic types (E1 and E2), and an adult type (A), generated by alternative RNA splicing from a single Drebrin gene. Drebrins are expressed mainly in brain neurons but are also found in skeletal muscle, heart, placenta, pancreas and kidney. Drebrin has been designated as a marker of the dendritic spine. Decreases in Drebrin levels in the brain have been been associated with Alzheimer s disease and Down syndrome.

Kreuzreaktivität (Details): Human.

Aufreinigung: 200ug/ml of Ab Purified from Bioreactor Concentrate.

Immunogen: Recombinant fragment (aa 150-281) of human DBN1 protein (exact sequence is proprietary)

Isotyp: IgG1, kappa

Anwendungsinformationen

Applikationshinweise:

Known_Application: Western Blot (1-2 μg/mL), Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 min at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes), Optimal dilution for a specific application should be determined.

Positive_Control: PC3 cells. Brain neurons. Also found in the heart, placenta, skeletal muscle, kidney and pancreas.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Konservierungsmittel: Azide free

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Haltbarkeit: 24 months

Details zu DBN1

Target: DBN1 (Drebrin 1 (DBN1))

Andere Bezeichnung: DBN1

Hintergrund:

Developmentally regulated brain protein, Drebrin 1, Drebrin, Drebrin E, Drebrin E2, Drebrin1, DrebrinE

kidney and pancreas., PC3 cells. Brain neurons. Also found in the heart, Placenta, Skeletal muscle

Molekulargewicht: 120kDa

Gen-ID: 1627, 130316

UniProt: Q16643

Pathways: Maintenance of Protein Location