CDw17 Antikörper
Reaktivität: Human
FACS, IF
Wirt: Maus
Monoclonal
HuLy-m13
unconjugated
-
- Target
- CDw17
- Reaktivität
- Human
-
Wirt
- Maus
-
Klonalität
- Monoklonal
-
Konjugat
- Unkonjugiert
-
Applikation
- Flow Cytometry (FACS), Immunofluorescence (IF)
- Spezifität
- CD17 is an intermediate glycosphingolipid from the metabolism of higher gangliosides that localizes to sphingolipid-sterol rafts. CD17 is detectable in monocytes, granulocytes, basophils, platelets, a subset of peripheral B cells (CD19+) and tonsil dendritic cells. It is rapidly down regulated on activated granulocytes and is upregulated on IL-2 activated T lymphocytes. CD17 binds to bacteria and may function in phagocytosis. VEGF-treated endothelial cells can produce CD17, which can then mediate signaling toward PECAM-1 expression and angiogenesis. Tumor necrosis factor )-induced astrogliosis (astrocyte proliferation and glial fibrillary acidic protein (GFAP) upregulation) in response to neuro-inflammation (i.e. spinal cord injury) causes an increase in intracellular levels of CD17. Aberrant levels of glycosphingolipids are a feature of cancer cells and may influence integrin clustering and internalization.
- Kreuzreaktivität (Details)
- Human.
- Aufreinigung
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
- Immunogen
- β-2 Microglobulin associated proteins from a detergent lysate of human PBL
- Klon
- HuLy-m13
- Isotyp
- IgM kappa
-
-
- Applikationshinweise
-
Known_Application: Flow Cytometry (1-2 μg/million cells), Immunofluorescence (1-2 μg/mL), Optimal dilution for a specific application should be determined.
Positive_Control: Human PBL. Tonsil.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
- Konzentration
- 1.0 mg/mL
- Buffer
- Purified Ab WITHOUT BSA at 1.0mg/ml
- Lagerung
- -20 °C,-80 °C
- Informationen zur Lagerung
- Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
- Haltbarkeit
- 24 months
-
- Target
- CDw17
- Hintergrund
-
Lactosylceramide; LacCer; β-D-galactosyl-(1-4)-β-D-glucosyl-(1-1')-ceramide;CDw17,CDw17 (Lactosylceramide or LacCer)
Cellular localisation: Cell Surface - Molekulargewicht
- Not known
-
Sie sind hier:
