CD8 alpha Antikörper (Cytoplasmic Domain)

Produktnummer ABIN6936856

Dieses Anti-CD8 alpha-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von CD8 alpha in ELISA und Coat. Geeignet für Human.

Kurzübersicht für CD8 alpha Antikörper (Cytoplasmic Domain) (ABIN6936856)

Target: CD8 alpha (CD8A) (CD8a Molecule (CD8A))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CD8 alpha Antikörper ist unkonjugiert

Applikation: ELISA, Coating (Coat)

Produktdetails anti-CD8 alpha Antikörper

Bindungsspezifität: Cytoplasmic Domain

Spezifität: CD8 is a cell surface receptor expressed either as a heterodimer with the CD8 beta chain (CD8 alpha/beta) or as a homodimer (CD8 alpha/alpha). A majority of thymocytes and a subpopulation of mature T cells and NK cell express CD8a. CD8 binds to MHC class 1 and through its association with protein tyrosine kinase p56lck plays a role in T cell development and activation of mature T cells. For mature T-cells, CD4 and CD8 are mutually exclusive, so anti-CD8, generally used in conjunction with anti-CD4. It is a useful marker for distinguishing helper/inducer T-lymphocytes, and most peripheral T-cell lymphomas are CD4+/CD8-. Anaplastic large cell lymphoma is usually CD4+ and CD8-, and in T-lymphoblastic lymphoma/leukemia, CD4 and CD8 are often co-expressed. CD8 is also found in littoral cell angioma of the spleen.

Kreuzreaktivität (Details): Human.

Immunogen: Recombinant fragment from C-terminal cytoplasmic domain of alpha chain of human CD8 (exact sequence is proprietary).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

Known_Application: ELISA (For coating, order Ab without BSA), Optimal dilution for a specific application should be determined.

Positive_Control: HuT78 or hPBL. Tonsil.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Konservierungsmittel: Azide free

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Haltbarkeit: 24 months

Details zu CD8 alpha

Target: CD8 alpha (CD8A) (CD8a Molecule (CD8A))

Andere Bezeichnung: CD8A

Hintergrund: CD8 antigen, alpha polypeptide (p32), T8/Leu-2 T-lymphocyte differentiation antigen, Ly3, LYT3, MAL, T-cell surface glycoprotein CD8 alpha chain,CD8A (Cytotoxic- & Suppressor T-Cell Marker)
Cellular localisation: Cell Surface

Molekulargewicht: 32kDa

Gen-ID: 925, 85258

UniProt: P01732

Pathways: T-Zell Rezeptor Signalweg