CD4 Antikörper

Produktnummer ABIN6936703

Der Maus Monoklonal anti-CD4 Antikörper (Klon EDU-2) (ABIN6936703) detektiert spezifisch CD4 in FACS, IF und Func. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für CD4 Antikörper (ABIN6936703)

Target: CD4

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CD4 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Immunofluorescence (IF), Functional Studies (Func)

Klon: EDU-2

Produktdetails anti-CD4 Antikörper

Spezifität: Recognizes a protein of 55 kDa, identified as CD4. It is a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigens and is also a receptor for the human immunodeficiency virus. This protein is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.This MAb was characterized as human CD4 antibody at II and IV International Workshop on Human Leukocyte Differentiation Antigens.

Keine Kreuzreaktivität: Rhesusaffen

Kreuzreaktivität (Details): Human. Chimpanzee. Orangutan. Macaca artctoids (Stumptail monkey). Does not react with Macaca mulatta (Rhesus Monkey).

Aufreinigung: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogen: Stimulated human leukocytes

Isotyp: IgG2a kappa

Anwendungsinformationen

Applikationshinweise:

Known_Application: Functional Studies (Order Ab without azide), Flow Cytometry (1-2 μg/million cells), Immunofluorescence (1-2 μg/mL), Optimal dilution for a specific application should be determined.

Positive_Control: Human peripheral blood mononuclear cells (PBMCs), CCRF-CEM or HL-60. Lymph node or tonsil.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Konservierungsmittel: Azide free

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Haltbarkeit: 24 months

Details zu CD4

Target: CD4

Andere Bezeichnung: CD4

Hintergrund: L3T4, Leu3, Ly-4, Lymphocyte antigen CD4, p55, T cell antigen T4/LEU3, T cell differentiation antigen L3T4, T-cell surface antigen T4/Leu-3, T-cell surface glycoprotein CD4,CD4 (T-Helper/Inducer Cell Marker)
Cellular localisation: Cell Surface

Molekulargewicht: 55kDa

Gen-ID: 920, 631659

UniProt: P01730

Pathways: T-Zell Rezeptor Signalweg, Maintenance of Protein Location, CXCR4-mediated Signaling Events