CD37 Antikörper

Produktnummer ABIN6936679

Dieses Anti-CD37-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von CD37 in FACS, IF, Func und DNA Mic. Geeignet für Human.

Kurzübersicht für CD37 Antikörper (ABIN6936679)

Target: CD37 (TSPAN26) (Tetraspanin 26 (TSPAN26))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CD37 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Immunofluorescence (IF), Functional Studies (Func), DNA Microscopy (DNA Mic)

Klon: IPO-24

Produktdetails anti-CD37 Antikörper

Spezifität: Recognizes a protein of 33-55kDa, identified as CD37 (Workshop V; Code CD37.7). CD37 is strongly expressed on normal and neoplastic mature (sIg+) B-lymphocytes. In B-cell ontogeny, CD37 appears after the pre-B-cell stage, is maintained during peripheral B-cell development and is lost upon terminal differentiation into plasma cells.1 CD37 is also present, at low densities, on resting and activated T cells, neutrophils, monocytes, and some myelomonocytic leukemia cells. It is absent from platelets, erythrocytes. CD37 is a member of a family of tetraspan transmembrane proteins, including CD9, CD53, CD63, CD81, and CD82. It associates other tetraspan transmembrane proteins and MHC class II molecules to form a large complex at the surface of B cells and play a role in signal transduction. CD37 is a valuable and stable marker for peripheral mature B-cells and corresponding malignancies like B-cell chronic lymphocytic leukemia (B-CLL), hairy cell leukemia (HCL), and all types of B-cell non-Hodgkin'' lymphoma (B-NHL).

Kreuzreaktivität (Details): Human.

Aufreinigung: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogen: Spleen cells of a patient with hairy cell leukemia

Isotyp: IgG2b kappa

Anwendungsinformationen

Applikationshinweise:

Known_Application: Functional Studies (Order Ab without Azide), Flow Cytometry (1-2 μg/million cells), Immunofluorescence (1-2 μg/mL), Optimal dilution for a specific application should be determined.

Positive_Control: Daudi, Raji, Namalva, Ramos cells and human lymphocytes. Human tonsil and lymph node.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Konservierungsmittel: Azide free

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Haltbarkeit: 24 months

Details zu CD37

Target: CD37 (TSPAN26) (Tetraspanin 26 (TSPAN26))

Andere Bezeichnung: CD37

Hintergrund: Cell differentiation antigen 37, GP52 40, Tetraspanin-26, Tspan-26, TSPAN26,CD37 (Peripheral Mature B-Cell Marker)
Cellular localisation: Cell Surface

Molekulargewicht: 33-55kDa

Gen-ID: 951, 166556

UniProt: P11049

Pathways: Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response