CD28 Antikörper

Produktnummer ABIN6936657

Der Maus Monoklonal Anti-CD28-Antikörper wurde für FACS, IF und Func validiert. Er ist geeignet, CD28 in Proben von Human zu detektieren.

Kurzübersicht für CD28 Antikörper (ABIN6936657)

Target: CD28

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CD28 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Immunofluorescence (IF), Functional Studies (Func)

Klon: CB28

Produktdetails anti-CD28 Antikörper

Spezifität: Recognizes a glycoprotein of 44-88 kDa, which is identified as CD28. Itis the critical T-cell co-stimulatory receptor which provides to the cell the important second activation signal by binding CD80 and CD86 that are expressed by antigen presenting cells. Besides its co-stimulation role, CD28 functions in preventing T-cells from anergic hyporesponsive state or from undergoing premature apoptotic cell death. CD28 is also expressed on human fetal NK cells and some NK cell lines, whereas on murine NK cells the CD28 expression is much broader.

Kreuzreaktivität (Details): Human.

Aufreinigung: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogen: Recombinant human CD28 protein

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise:

Known_Application: Flow Cytometry (1-2 μg/million cells), ,Immunofluorescence (1-2 μg/mL), ,Functional Studies (Order Ab without BSA & Azide), ,Optimal dilution for a specific application should be determined.

Positive_Control: Jurkat cells.Human lymph nodes and tonsils.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Konservierungsmittel: Azide free

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Haltbarkeit: 24 months

Details zu CD28

Target: CD28

Andere Bezeichnung: CD28

Hintergrund: T-cell-specific surface glycoprotein CD28, Tp44,CD28
Cellular localisation: Cell Surface

Molekulargewicht: 44kDa (monomer), 88kDa (dimer)

Gen-ID: 940, 591629

UniProt: P10747

Pathways: T-Zell Rezeptor Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response