BAP1 Antikörper (AA 191-326)

Produktnummer ABIN6936460

Produktdetails anti-BAP1 Antikörper

Target: BAP1 (BRCA1 Associated Protein-1 (Ubiquitin Carboxy-terminal Hydrolase) (BAP1))

Bindungsspezifität: AA 191-326

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser BAP1 Antikörper ist unkonjugiert

Applikation: ELISA, Coating (Coat)

Spezifität: The BAP1 gene belongs to the ubiquitin C-terminal hydrolase subfamily of de-ubiquitination enzymes that are involved in the removal of ubiquitin from proteins. The encoded enzyme binds to the breast cancer type 1 susceptibility protein (BRCA1) via the RING finger domain of the latter and acts as a tumor suppressor. In addition, the enzyme may be involved in regulation of transcription, regulation of cell cycle and growth, response to DNA damage and chromatin dynamics. Germ line mutations in this gene may be associated with tumor predisposition syndrome (TPDS), which involves increased risk of cancers including malignant mesothelioma, Uveal melanoma and cutaneous melanoma.

Kreuzreaktivität (Details): Human.

Aufreinigung: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogen: Recombinant human BAP1 protein fragment (around aa 191-326) (exact sequence is proprietary)

Klon: BAP1-2431

Isotyp: IgG2c kappa

Anwendungsinformationen

Applikationshinweise:

Known_Application: ELISA (For coating, order Ab without BSA), Optimal dilution for a specific application should be determined.

Positive_Control: Jurkat or PC-3 or HepG2 cells. Testis, Placenta, Ovarian or Breast Carcinoma.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Konservierungsmittel: Azide free

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Haltbarkeit: 24 months

Details zu BAP1

Target: BAP1 (BRCA1 Associated Protein-1 (Ubiquitin Carboxy-terminal Hydrolase) (BAP1))

Andere Bezeichnung: BAP1 (BAP1 Produkte)

Synonyme: HUCEP-13 antikoerper, UCHL2 antikoerper, BAIAP3 antikoerper, 2300006C11Rik antikoerper, AA989761 antikoerper, AW553466 antikoerper, mKIAA0272 antikoerper, uch-x4 antikoerper, hucep-13 antikoerper, hucep-6 antikoerper, uchl2 antikoerper, si:dkey-42i9.9 antikoerper, BRCA1 associated protein 1 antikoerper, Brca1 associated protein 1 antikoerper, BRCA1 associated protein 1 L homeolog antikoerper, BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase) antikoerper, BAP1 antikoerper, Bap1 antikoerper, bap1.L antikoerper, bap1 antikoerper

Hintergrund: BAP1, BRCA1 associated protein 1, Cerebral protein 13, Cerebral protein 6, HUCEP 13, Hucep 6, HUCEP13, Hucep6, TPDS, Ubiquitin carboxy terminal hydrolase, Ubiquitin carboxyl terminal hydrolase BAP1, UCHL2,BAP1 (BRCA1 Associated Protein 1)
Cellular localisation: Nuclear and Cytoplasmic

Molekulargewicht: 91kDa

Gen-ID: 8314, 106674

UniProt: Q92560