Annexin a1 Antikörper

Produktnummer ABIN6936421

Der Maus Monoklonal anti-Annexin a1 Antikörper (Klon CPTC-ANXA1-1) (ABIN6936421) detektiert spezifisch Annexin a1 in WB und IHC. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus, Ratte, Kaninchen und Hamster.

Kurzübersicht für Annexin a1 Antikörper (ABIN6936421)

Target: Annexin a1 (ANXA1) (Annexin A1 (ANXA1))

Reaktivität: Human, Maus, Ratte, Kaninchen, Hamster

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Annexin a1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Klon: CPTC-ANXA1-1

Produktdetails anti-Annexin a1 Antikörper

Verwendungszweck: Annexin A1 / (Hairy Cell Leukemia Marker) Antibody

Spezifität: The ANXA1 gene belongs to the annexin family, and contains 4 annexin repeats. A pair of annexin repeats may form one binding site for calcium and a phospholipid. ANXA1 promotes membrane fusion and is involved in exocytosis. The gene for ANXA1 is upregulated in hairy cell leukemia (HCL), and its protein expression is specific for HCL. Detection of ANXA1 provides a simple, highly sensitive and specific assay for diagnosing HCL. Annexin A1 has also been found to be protective against DNA damage induced by heat in breast cancer cells, suggesting it is involved in tumor suppressive and protective activities, and also is associated with treatment resistance.

Kreuzreaktivität (Details): Human.

Aufreinigung: 200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant full-length human Annexin A1 protein

Isotyp: IgG2a, kappa

Anwendungsinformationen

Applikationshinweise:

Known_Application: Immunoprecipitation (2-4 μg/mg protein), Western Blot (1-2 μg/mL), ,Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 min at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes), Optimal dilution for a specific application should be determined.

Positive_Control: A549, A431 and K562 cell lysates, human esophagus, placenta and prostate tissues.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Konservierungsmittel: Azide free

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Haltbarkeit: 24 months

Details zu Annexin a1

Target: Annexin a1 (ANXA1) (Annexin A1 (ANXA1))

Andere Bezeichnung: ANXA1

Hintergrund:

ANXA1, ANX1, Annexin-1, Chromobindin-9, LPC1, p35

A431 and K562 cell lysates, A549, human esophagus, Human Intestine, Lung, placenta and prostate tissues.

Molekulargewicht: 38kDa

Gen-ID: 301, 494173

UniProt: P04083

Pathways: Hormone Transport