AKR1B1 Antikörper

Produktnummer ABIN6936373

Dieses Anti-AKR1B1-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von AKR1B1 in WB, IF und IHC (f). Geeignet für Human.

Kurzübersicht für AKR1B1 Antikörper (ABIN6936373)

Target: AKR1B1 (Aldo-Keto Reductase Family 1, Member B1 (Aldose Reductase) (AKR1B1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser AKR1B1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))

Klon: CPTC-AKR1B1-3

Produktdetails anti-AKR1B1 Antikörper

Spezifität: AKR1B1, also designated as aldose reductase, is a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This protein catalyzes the reduction of a number of aldehydes, including the aldehyde form of glucose, and is thereby implicated in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol. It has also been shown to have decreased expression in adrenocortical cancer, and possibly play a role in adrenal tumorigenesis. It has been suggested that AKR1B1 could be investigated as a marker of malignancy for adrenal tumor diagnosis.

Kreuzreaktivität (Details): Human.

Aufreinigung: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogen: Recombinant human full-length AKR1B1 protein

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise:

Known_Application: Western Blot (1-2 μg/mL),Immunofluorescence (1-2 μg/mL),Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 min at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes), Optimal dilution for a specific application should be determined.

Positive_Control: 293T, HEK293, A431, HeLa, HepG2, MOLT4, Jurkat and Raji whole cell lysates, Human Kidney, Human colon carcinoma tissue.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Konservierungsmittel: Azide free

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Haltbarkeit: 24 months

Details zu AKR1B1

Target: AKR1B1 (Aldo-Keto Reductase Family 1, Member B1 (Aldose Reductase) (AKR1B1))

Andere Bezeichnung: AKR1B1

Hintergrund: AKR1B1, Aldehyde reductase, aldehyde reductase 1, Aldo-keto reductase family 1 member B1, aldo-keto reductase family 1, member B1 (aldose reductase), Aldose reductase, AR, Lii5-2 CTCL tumor antigen, low Km aldose reductase,Aldo-keto Reductase Family 1 Member B1 (Adrenal Marker)
Cellular localisation: Cytoplasmic

Molekulargewicht: 37kDa

Gen-ID: 231, 521212

UniProt: P15121

Pathways: Metabolism of Steroid Hormones and Vitamin D, C21-Steroid Hormone Metabolic Process, Monocarboxylic Acid Catabolic Process