alpha Actinin 4 Antikörper
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- Target Alle alpha Actinin 4 (ACTN4) Antikörper anzeigen
- alpha Actinin 4 (ACTN4) (Actinin, alpha 4 (ACTN4))
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Reaktivität
- Human
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Dieser alpha Actinin 4 Antikörper ist unkonjugiert
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Applikation
- Immunohistochemistry (IHC), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
- Spezifität
- The spectrin gene family encodes a diverse group of cytoskeletal proteins that include spectrins, dystrophins and -actinins. There are four tissue-specific -actinins, namely -actinin-1, -actinin-2, -actinin-3 and -actinin-4, which are localized to muscle and non-muscle cells, including skeletal, cardiac and smooth muscle cells, as well as within the cytoskeleton. Each -actinin protein contains one Actin-binding domain, two calponin-homology domains, two EF-hand domains and four spectrin repeats, through which they function as bundling proteins that can cross-link F-Actin, thus anchoring Actin to a variety of intracellular structures. Defects in the gene encoding -actinin-4 are the cause of focal segmental glomerulosclerosis 1 (FSGS1), a common renal lesion characterized by decreasing kidney function and, ultimately, renal failure.
- Kreuzreaktivität (Details)
- Human.
- Aufreinigung
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
- Immunogen
- Recombinant full-length human ACTN4 protein
- Klon
- 93
- Isotyp
- IgG
- Top Product
- Discover our top product ACTN4 Primärantikörper
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- Applikationshinweise
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Known_Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes), Optimal dilution for a specific application should be determined.
Positive_Control: Human colon or kidney tissue (IHC).
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Konzentration
- 1.0 mg/mL
- Buffer
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
- Konservierungsmittel
- Azide free
- Lagerung
- -20 °C,-80 °C
- Informationen zur Lagerung
- Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
- Haltbarkeit
- 24 months
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- Target
- alpha Actinin 4 (ACTN4) (Actinin, alpha 4 (ACTN4))
- Andere Bezeichnung
- ACTN4 (ACTN4 Produkte)
- Synonyme
- fsgs antikoerper, fsgs1 antikoerper, C77391 antikoerper, ACTININ-4 antikoerper, FSGS antikoerper, FSGS1 antikoerper, wu:fb53f05 antikoerper, zgc:63508 antikoerper, actinin alpha 4 antikoerper, actinin, alpha 4 antikoerper, actinin alpha 4 S homeolog antikoerper, actn4 antikoerper, ACTN4 antikoerper, Actn4 antikoerper, actn4.S antikoerper
- Hintergrund
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F-actin cross-linking protein, Focal segmental glomerulosclerosis 1 (FSG1), Non-muscle alpha-actinin-4,Alpha Actinin 4 / ACTN4
Cellular localisation: Nucleus. Cytoplasm. - Molekulargewicht
- 105kDa
- Gen-ID
- 81, 270291
- UniProt
- O43707
- Pathways
- Proton Transport
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