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GPER Antikörper (AA 251-375)

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch GPER in WB, FACS, IF (cc), IF (p), IHC (p), ELISA und IHC (fro). Er zeigt eine Reaktivität gegenüber Human, Maus und Ratte und wurde in 3+ Publikationen erwähnt.
Produktnummer ABIN685717

Kurzübersicht für GPER Antikörper (AA 251-375) (ABIN685717)

Target

Alle GPER Antikörper anzeigen
GPER (G Protein-Coupled Estrogen Receptor 1 (GPER))

Reaktivität

  • 95
  • 62
  • 51
  • 5
  • 4
  • 3
  • 2
  • 1
Human, Maus, Ratte

Wirt

  • 96
  • 1
  • 1
Kaninchen

Klonalität

  • 97
  • 1
Polyklonal

Konjugat

  • 36
  • 6
  • 6
  • 5
  • 5
  • 4
  • 4
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 2
  • 2
  • 1
Dieser GPER Antikörper ist unkonjugiert

Applikation

  • 75
  • 42
  • 38
  • 38
  • 20
  • 14
  • 12
  • 9
  • 8
  • 8
  • 5
  • 1
Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro))
  • Bindungsspezifität

    • 16
    • 16
    • 15
    • 9
    • 9
    • 7
    • 7
    • 6
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 251-375

    Kreuzreaktivität

    Human, Maus, Ratte

    Homologie

    Cow,Horse,Chicken,Rabbit

    Aufreinigung

    Purified by Protein A.

    Immunogen

    KLH conjugated synthetic peptide derived from human GPR30

    Isotyp

    IgG
  • Applikationshinweise

    WB 1:300-5000
    ELISA 1:500-1000
    FCM 1:20-100
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    1 μg/μL

    Buffer

    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

    Konservierungsmittel

    ProClin

    Vorsichtsmaßnahmen

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

    Haltbarkeit

    12 months
  • Wang, Alencar, Lin, Sun, Sudo, Zapata-Sudo, Lowe, Groban: "Activation of GPR30 improves exercise capacity and skeletal muscle strength in senescent female Fischer344 × Brown Norway rats." in: Biochemical and biophysical research communications, Vol. 475, Issue 1, pp. 81-6, (2016) (PubMed).

    Wang, Zhao, Lin, Groban: "Activation of GPR30 inhibits cardiac fibroblast proliferation." in: Molecular and cellular biochemistry, Vol. 405, Issue 1-2, pp. 135-48, (2015) (PubMed).

    Zhao, Wang, Lin, Groban: "GPR30 decreases cardiac chymase/angiotensin II by inhibiting local mast cell number." in: Biochemical and biophysical research communications, Vol. 459, Issue 1, pp. 131-6, (2015) (PubMed).

  • Target

    GPER (G Protein-Coupled Estrogen Receptor 1 (GPER))

    Andere Bezeichnung

    GPR30

    Hintergrund

    Synonyms: mER, CEPR, GPER, DRY12, FEG-1, GPR30, LERGU, LyGPR, CMKRL2, LERGU2, GPCR-Br, G-protein coupled estrogen receptor 1, Chemoattractant receptor-like 2, Flow-induced endothelial G-protein coupled receptor 1, G protein-coupled estrogen receptor 1, G-protein coupled receptor 30, IL8-related receptor DRY12, Lymphocyte-derived G-protein coupled receptor, Membrane estrogen receptor, GPER1

    Background: G-protein coupled estrogen receptor that binds to 17-beta-estradiol (E2) with high affinity, leading to rapid and transient activation of numerous intracellular signaling pathways. Stimulates cAMP production, calcium mobilization and tyrosine kinase Src inducing the release of heparin-bound epidermal growth factor (HB-EGF) and subsequent transactivation of the epidermal growth factor receptor (EGFR), activating downstream signaling pathways such as PI3K/Akt and ERK/MAPK. Mediates pleiotropic functions among others in the cardiovascular, endocrine, reproductive, immune and central nervous systems. Has a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a RAMP3-dependent manner. Regulates arterial blood pressure by stimulating vasodilation and reducing vascular smooth muscle and microvascular endothelial cell proliferation. Plays a role in blood glucose homeostasis contributing to the insulin secretion response by pancreatic beta cells. Triggers mitochondrial apoptosis during pachytene spermatocyte differentiation. Stimulates uterine epithelial cell proliferation. Enhances uterine contractility in response to oxytocin. Contributes to thymic atrophy by inducing apoptosis. Attenuates TNF-mediated endothelial expression of leukocyte adhesion molecules. Promotes neuritogenesis in developing hippocampal neurons. Plays a role in acute neuroprotection against NMDA-induced excitotoxic neuronal death. Increases firing activity and intracellular calcium oscillations in luteinizing hormone-releasing hormone (LHRH) neurons. Inhibits early osteoblast proliferation at growth plate during skeletal development. Inhibits mature adipocyte differentiation and lipid accumulation. Involved in the recruitment of beta-arrestin 2 ARRB2 at the plasma membrane in epithelial cells.

    Gen-ID

    2852

    UniProt

    Q99527

    Pathways

    EGFR Signaling Pathway, Positive Regulation of Peptide Hormone Secretion, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Carbohydrate Homeostasis, cAMP Metabolic Process, Regulation of G-Protein Coupled Receptor Protein Signaling, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process
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