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MMP26 Antikörper (AA 185-261) (Cy7)

This anti-MMP26 antibody (ABIN685693) is a Rabbit Polyclonal antibody detecting MMP26 in WB, IF (cc), IF (p). Suitable for Human.
Produktnummer ABIN685693

Kurzübersicht für MMP26 Antikörper (AA 185-261) (Cy7) (ABIN685693)

Target

Alle MMP26 Antikörper anzeigen
MMP26 (Matrix Metallopeptidase 26 (MMP26))

Reaktivität

  • 39
  • 2
  • 2
  • 1
Human

Wirt

  • 33
  • 6
Kaninchen

Klonalität

  • 33
  • 6
Polyklonal

Konjugat

  • 15
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser MMP26 Antikörper ist konjugiert mit Cy7

Applikation

  • 33
  • 14
  • 12
  • 12
  • 3
  • 3
  • 2
  • 2
  • 2
  • 1
Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
  • Bindungsspezifität

    • 14
    • 7
    • 3
    • 3
    • 2
    • 1
    • 1
    AA 185-261

    Kreuzreaktivität

    Human

    Aufreinigung

    Purified by Protein A.

    Immunogen

    KLH conjugated synthetic peptide derived from human MMP26 intermedial

    Isotyp

    IgG
  • Applikationshinweise

    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    1 μg/μL

    Buffer

    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

    Konservierungsmittel

    ProClin

    Vorsichtsmaßnahmen

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

    Haltbarkeit

    12 months
  • Target

    MMP26 (Matrix Metallopeptidase 26 (MMP26))

    Andere Bezeichnung

    Mmp-26

    Hintergrund

    Synonyms: MMP26_HUMAN, Endometase, Matrilysin 2, MMP26, Matrix Metalloproteinase 26, MMP 26.

    Background: Matrix metalloproteinase 26 preprotein, gelatinase A, 70kD type IV collagenase, gelatinase neutrophil. Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes as well as in disease processes. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. MMP26 degrades type IV collagen, the major structural component of basement membranes. The enzyme plays a role in endometrial menstrual breakdown, regulation of vascularization and the inflammatory response.Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. MMP26, also known as Matrilysin 2, was first cloned from human fetal cells, and identified as an MMP most closely related to MMP7 (Matrilysin 1). The homology between MMP7 and MMP26 is low (only 38 % identical), thus the functions are unlikely to be similar. Homology is much higher (48 % identical) for the comparable region of MMP12, but MMP26 appears to have broader substrate specificity than does MMP12. MMP26, like MMP7, lacks the hemopexin domain common to the other MMPs, but contains a Propeptide domain, cysteine switch activation site, followed by a catalytic domain, and a short vestige of the hinge region. MMP26 is apparently not glycosylated, and is a secreted MMP. Tissue analysis shows MMP26 most strongly in placenta and uterus, but also in kidney cells, lung cells, lymphocytes and lung or endometrial carcinoma cells. MMP26 is proteolytically active, cleaving casein in zymograms, and gelatin, a1PI, fibrinogen, fibronectin, vitronectin, type IV collagen, and apparently activating MMP9.

    Gen-ID

    56547
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