SNAI1, SNAI2, SNAI3 (AA 188-264) Antikörper

Produktnummer ABIN685597

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch SNAI1, SNAI2, SNAI3 in ELISA, FACS, IF (cc), IF (p), IHC (fro), IHC (p) und WB. Es zeigt Reaktivität gegenüber Proben von Human und Kaninchen.Es wurde in 1 Publikation zitiert.

Kurzübersicht für SNAI1, SNAI2, SNAI3 (AA 188-264) Antikörper (ABIN685597)

Target: SNAI1, SNAI2, SNAI3

Reaktivität: Human, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Applikation: ELISA, Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)

Produktdetails

Bindungsspezifität: AA 188-264

Kreuzreaktivität: Human, Kaninchen

Homologie: Mouse,Rat

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Snail

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Referenzen

Takahashi, Akamatsu, Yagami, Hasegawa, Ohgo, Abe, Iwata, Arima, Mizutani, Nakata, Matsunaga: "Epithelial-mesenchymal transition of the eccrine glands is involved in skin fibrosis in morphea." in: The Journal of dermatology, Vol. 40, Issue 9, pp. 720-5, (2013) (PubMed).

Antigendetails

Target: SNAI1, SNAI2, SNAI3

Hintergrund:

Synonyms: dJ710H13.1, Protein sna, Protein snail homolog, SLUGH2, SNA, Sna protein, SNAH, SNAI1, Snail homolog 1 Drosophila, Zinc finger protein SNAI1, SNAI1_HUMAN, Protein snail homolog 1, dJ710H13.1, SNAIL, SNAIL1, Protein sna, SLUG, WS2D, SLUGH, SLUGH1, SNAIL2, SMUC, SNAIL3, ZNF293, Zfp293

Background: The zinc finger transcription factor 'SNAIL' was first identified in Drosophila and, along with 'twist', a basic helix-loop-helix transcription factor, is indispensable for mesoderm formation. SNAIL is a repressor of mouse E-cadherin transcription, with expression of SNAIL inversely correlated with expression of E-cadherin. Abnormal expression of SNAIL could underlie the tumorigenic conversion of epithelia associated with loss of E-cadherin expression through screening mouse and human cell lines and by in situ hybridization of primary human tumors undergoing malignant progression.

Molekulargewicht: 29kDa

Gen-ID: 6615, 6591, 333929

UniProt: Q02085, P97469, Q9QY31