BCR Antikörper (pTyr177) (Cy3)

Produktnummer ABIN683656

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch BCR in WB, FACS, IF (cc) und IF (p). Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für BCR Antikörper (pTyr177) (Cy3) (ABIN683656)

Target: BCR (Breakpoint Cluster Region (BCR))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BCR Antikörper ist konjugiert mit Cy3

Applikation: Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Produktdetails anti-BCR Antikörper (Cy3)

Bindungsspezifität: pTyr177

Kreuzreaktivität: Human

Homologie: Mouse,Rat,Pig,Rabbit,Guinea Pig

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from human Bcr around the phosphorylation site of Tyr177 [PF(p-Y)VN]

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: FCM 1:20-100
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu BCR

Target: BCR (Breakpoint Cluster Region (BCR))

Andere Bezeichnung: Bcr

Hintergrund:

Synonyms: Bcr phospho Y177, BcrTyr177, ALL, BCR 1, BCR/ABL FUSION GENE INCLUDED, BCR/FGFR1 FUSION GENE INCLUDED, BCR/PDGFRA FUSION GENE INCLUDED, BCR1, breakpoint cluster region, CML, PHL, BCR_HUMAN.

Background: The breakpoint cluster region protein (Bcr) is best know to be involved in genomic translocation with fusion partner Abl (Cbr-Abl) causing chronic myelogenous leukemia (CML). This 160 kDa protein contains a serine/threonine kinase domain, an SH2 binding domain, a GTP/GDP exchange domain and a C-term domain which functions as a GTPase activating protein for p21rac and CDC42. Additionally, Bcr is involved in signal transduction and can down regulate Ras mediated cell signaling.

Gen-ID: 613

Pathways: Regulation of Leukocyte Mediated Immunity, Platelet-derived growth Factor Receptor Signaling