ARHGAP17 Antikörper (AA 451-550)

Produktnummer ABIN679343

Der Kaninchen Polyklonal Anti-ARHGAP17-Antikörper wurde für ELISA, IHC (p), IF (cc), IF (p) und IHC (fro) validiert. Er ist geeignet, ARHGAP17 in Proben von Ratte zu detektieren.

Kurzübersicht für ARHGAP17 Antikörper (AA 451-550) (ABIN679343)

Target: ARHGAP17 (rho GTPase Activating Protein 17 (ARHGAP17))

Reaktivität: Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ARHGAP17 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Produktdetails anti-ARHGAP17 Antikörper

Bindungsspezifität: AA 451-550

Kreuzreaktivität: Ratte

Homologie: Human,Mouse,Drosophila

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from fruit fly ARHGAP17/Nadrin

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu ARHGAP17

Target: ARHGAP17 (rho GTPase Activating Protein 17 (ARHGAP17))

Andere Bezeichnung: ARHGAP17

Hintergrund:

Synonyms: ARHGAP17, NADRIN, Neuron associated developmentally regulated protein, Rho GTPase activating protein 17, RhoGAP interacting with CIP4 homologs protein 1, RICH 1, RICH1, WBP15, MST066, MST110, MSTP038, PP367, PP4534, Rho type GTPase activating protein 17, RhoGAP interacting with CIP4 homologs 1, RICH1B.

Background: ARHGAP17 is a Rho GTPase-activating protein involved in the maintenance of tight junction by regulating the activity of CDC42, thereby playing a central role in apical polarity of epithelial cells. It specifically acts as a GTPase activator for the CDC42 GTPase by converting it to an inactive GDP-bound state. The complex formed with AMOT acts by regulating the uptake of polarity proteins at tight junctions, possibly by deciding whether tight junction transmembrane proteins are recycled back to the plasma membrane or sent elsewhere. RHGAP17 participates in the Ca(2+)-dependent regulation of exocytosis, possibly by catalyzing GTPase activity of Rho family proteins and by inducing the reorganization of the cortical actin filaments. Acts as a GTPase activator in vitro for RAC1.

Gen-ID: 55114