Uromodulin Antikörper (AA 351-450)

Produktnummer ABIN678473

Der Kaninchen Polyklonal Anti-Uromodulin-Antikörper wurde für WB, ELISA, IHC (p), FACS, IF (cc), IF (p) und IHC (fro) validiert. Er ist geeignet, Uromodulin in Proben von Human, Maus und Ratte zu detektieren. Es sind 2+ Publikationen verfügbar.

Kurzübersicht für Uromodulin Antikörper (AA 351-450) (ABIN678473)

Target: Uromodulin (UMOD)

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Uromodulin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Produktdetails anti-Uromodulin Antikörper

Bindungsspezifität: AA 351-450

Kreuzreaktivität: Human, Maus, Ratte

Homologie: Cow

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from Human Uromodulin

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Referenzen für anti-Uromodulin Antikörper (ABIN678473)

Cho, Song, Oh, Kim, Ko, Lee, Jo: "Fate of Neutrophils during the Recovery Phase of Ischemia/Reperfusion Induced Acute Kidney Injury." in: Journal of Korean medical science, Vol. 32, Issue 10, pp. 1616-1625, (2018) (PubMed).

Kim, Ko, Lee, Kim, Jo, Cho: "Blocking junctional adhesion molecule C promotes the recovery of cisplatin-induced acute kidney injury." in: The Korean journal of internal medicine, Vol. 32, Issue 6, pp. 1053-1061, (2018) (PubMed).

Details zu Uromodulin

Target: Uromodulin (UMOD)

Andere Bezeichnung: Uromodulin

Hintergrund:

Synonyms: ADMCKD2, FJHN, HNFJ, HNFJ1, MCKD2, medullary cystic kidney disease 2 autosomal dominant, Tamm Horsfall glycoprotein, Tamm Horsfall urinary glycoprotein, Tamm-Horsfall urinary glycoprotein, THGP, THP, Umod, UROM_HUMAN, Uromodulin.

Background: Uromodulin: Functions in biogenesis and organization of the apical membrane of epithelial cells of the thick ascending limb of Henle's loop (TALH), where it promotes formation of complex filamentous gel-like structure providing the water barrier permeability. May serve as a receptor for binding and endocytosis for cytokines (IL-1, IL-2) and TNF. Facilitates neutrophil migration across renal epithelia. Uromodulin, secreted form: Secreted into urine after proteolytical cleavage. Into the urine, may contribute to colloid osmotic pressure, retards passage of positively charged electrolytes, prevents urinary tract infection and modulates formation of supersaturated salts and their crystals.

Gen-ID: 7369

UniProt: P07911