AU5 Epitope Tag Antikörper

Produktnummer ABIN677708

Der Kaninchen Polyklonal Anti-AU5 Epitope Tag-Antikörper wurde für ELISA und ICC validiert. Er ist geeignet, AU5 Epitope Tag in Proben von Tag zu detektieren.

Kurzübersicht für AU5 Epitope Tag Antikörper (ABIN677708)

Target: AU5 Epitope Tag (TDFYLK)

Reaktivität: Tag

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser AU5 Epitope Tag Antikörper ist unkonjugiert

Applikation: ELISA, Immunocytochemistry (ICC)

Produktdetails anti-AU5 Epitope Tag Antikörper

Sequenz: TDFYLK

Kreuzreaktivität: Tag

Kreuzreaktivität (Details): fusion protein,tagged T7 tag

Produktmerkmale: Antibody is specific for: fusion protein,tagged T7 tag

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated to AU5 tag

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA 1:500-1000
ICC 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu AU5 Epitope Tag

Target: AU5 Epitope Tag (TDFYLK)

Andere Bezeichnung: AU5 tag

Substanzklasse: Tag

Hintergrund:

Synonyms: AU5 epitope tag, TDFYLK epitope tag, TDFYLK tag.

Background: Core protein packages viral RNA to form a viral nucleocapsid, and promotes virion budding. Modulates viral translation initiation by interacting with HCV IRES and 40S ribosomal subunit. Also regulates many host cellular functions such as signaling pathways and apoptosis. Prevents the establishment of cellular antiviral state by blocking the interferon-alpha/beta (IFN-alpha/beta) and IFN-gamma signaling pathways and by inducing human STAT1 degradation. Plays an important role in virus-mediated cell transformation leading to hepatocellular carcinomas. Interacts with, and activates STAT3 leading to cellular transformation. May repress the promoter of p53, and sequester CREB3 and SP110 isoform3/Sp110b in the cytoplasm. Also represses cell cycle negative regulating factor CDKN1A, thereby interrupting an important check point of normal cell cycle regulation. Targets transcription factors involved in the regulation of inflammatory responses and in the immune response: suppresses NK-kappaB activation, and activates AP-1. Mediates apoptotic pathways throught association with TNF-type receptors TNFRSF1A and LTBR, although its effect on death receptors-induced apoptosis remains controvertial. Enhances TRAIL mediated apoptosis, suggesting that it might play a role in mediated apoptosis, suggesting that it might play a role in immune-mediated liver cell injury. Secreted core protein is able to bind C1QR1 at the T-cell surface, resulting in down-regulation of T-lymphocytes proliferation. May transactivate human MYC, Rous sarcoma virus LTR, and SV40 promoters. May suppress the human FOS and HIV-1 LTR activity. May alter lipid metabolism by interacting with hepatocellular proteins involved in lipid accumulation and storage.