CCL5 Antikörper (AA 62-91)

Produktnummer ABIN674949

Dieses Anti-CCL5-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von CCL5 in ELISA, IHC (p), IF (cc), IF (p) und IHC (fro). Geeignet für Human, Maus, Meerschweinchen und Schwein. Dieses Primary Antibody wurde in 7+ Publikationen zitiert.

Kurzübersicht für CCL5 Antikörper (AA 62-91) (ABIN674949)

Target: CCL5 (Chemokine (C-C Motif) Ligand 5 (CCL5))

Reaktivität: Human, Maus, Meerschweinchen, Schwein

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CCL5 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Produktdetails anti-CCL5 Antikörper

Bindungsspezifität: AA 62-91

Kreuzreaktivität: Meerschweinchen, Human, Maus, Schwein

Homologie: Rat,Dog,Cow,Sheep,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human CCL5

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Referenzen für anti-CCL5 Antikörper (ABIN674949)

Irie, Tomofuji, Ekuni, Fukuhara, Uchida, Kataoka, Kobayashi, Kikuchi, Mitani, Shimazaki, Morita: "Age-related changes of CD4+T cell migration and cytokine expression in germ-free and SPF mice periodontium." in: Archives of oral biology, Vol. 87, pp. 72-78, (2018) (PubMed).

Sun, Roberts, Mauerhan, Hanley: "Biological effects and osteoarthritic disease-modifying activity of small molecule CM-01." in: Journal of orthopaedic research : official publication of the Orthopaedic Research Society, (2017) (PubMed).

Sun, Haines, Roberts, Ruffolo, Mauerhan, Mihalko, Ingram, Cox, Hanley: "Disease-modifying effects of phosphocitrate and phosphocitrate-β-ethyl ester on partial meniscectomy-induced osteoarthritis." in: BMC musculoskeletal disorders, Vol. 16, pp. 270, (2016) (PubMed).

Hwaiz, Rahman, Syk, Zhang, Thorlacius: "Rac1-dependent secretion of platelet-derived CCL5 regulates neutrophil recruitment via activation of alveolar macrophages in septic lung injury." in: Journal of leukocyte biology, (2015) (PubMed).

Herder, Iskandar, Kegler, Hansmann, Elmarabet, Khan, Kalkuhl, Deschl, Baumgärtner, Ulrich, Beineke: "Dynamic Changes of Microglia/Macrophage M1 and M2 Polarization in Theiler's Murine Encephalomyelitis." in: Brain pathology (Zurich, Switzerland), Vol. 25, Issue 6, pp. 712-23, (2015) (PubMed).

Pattappa, Peroglio, Sakai, Mochida, Benneker, Alini, Grad: "CCL5/RANTES is a key chemoattractant released by degenerative intervertebral discs in organ culture." in: European cells & materials, Vol. 27, pp. 124-36; discussion 136, (2014) (PubMed).

Details zu CCL5

Target: CCL5 (Chemokine (C-C Motif) Ligand 5 (CCL5))

Andere Bezeichnung: CCL5/RANTES

Hintergrund:

Synonyms: SISd, eoCP, SCYA5, RANTES, TCP228, D17S136E, SIS-delta, C-C motif chemokine 5, Eosinophil chemotactic cytokine, Small-inducible cytokine A5, T cell-specific protein P228, T-cell-specific protein RANTES, CCL5

Background: Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant RANTES protein induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form RANTES(3-68) acts as a natural chemotaxis inhibitor and is a more potent inhibitor of HIV-1-infection. The second processed form RANTES(4-68) exhibits reduced chemotactic and HIV-suppressive activity compared with RANTES(1-68) and RANTES(3-68) and is generated by an unidentified enzyme associated with monocytes and neutrophils (PubMed:1679162, PubMed:13864, PubMed:8525373, PubMed:9516414, PubMed:15923218). May also be an agonist of the G protein-coupled receptor GPR75, stimulating inositol trisphosphate production and calcium mobilization through its activation. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells (PubMed:23979485).

Gen-ID: 6352

UniProt: P13501

Pathways: Cellular Response to Molecule of Bacterial Origin, Regulation of G-Protein Coupled Receptor Protein Signaling, Smooth Muscle Cell Migration