TP53BP2 Antikörper (AA 1001-1128)

Produktnummer ABIN674394

Dieses Anti-TP53BP2-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von TP53BP2 in WB, ELISA und IHC (p). Geeignet für Human und Maus. Dieses Primary Antibody wurde in 1 Publikation zitiert.

Kurzübersicht für TP53BP2 Antikörper (AA 1001-1128) (ABIN674394)

Target: TP53BP2 (Tumor Protein P53 Binding Protein 2 (TP53BP2))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TP53BP2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-TP53BP2 Antikörper

Bindungsspezifität: AA 1001-1128

Kreuzreaktivität: Human, Maus

Homologie: Rat,Chicken

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human ASPP2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Referenzen für anti-TP53BP2 Antikörper (ABIN674394)

Xie, Yang, Chi, Yang, Wang, Xu: "Prognostic values of apoptosis-stimulating P53-binding protein 1 and 2 and their relationships with clinical characteristics of esophageal squamous cell carcinoma patients: a retrospective study." in: Chinese journal of cancer, Vol. 36, Issue 1, pp. 15, (2017) (PubMed).

Details zu TP53BP2

Target: TP53BP2 (Tumor Protein P53 Binding Protein 2 (TP53BP2))

Andere Bezeichnung: ASPP2/p53BP2

Hintergrund:

Synonyms: BBP, 53BP2, ASPP2, P53BP2, PPP1R13A, Apoptosis-stimulating of p53 protein 2, Bcl2-binding protein, Renal carcinoma antigen NY-REN-51, Tumor suppressor p53-binding protein 2, p53-binding protein 2, TP53BP2

Background: Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions. Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. Inhibits the ability of APPBP1 to conjugate NEDD8 to CUL1, and thereby decreases APPBP1 ability to induce apoptosis. Impedes cell cycle progression at G2/M. Its apoptosis-stimulating activity is inhibited by its interaction with DDX42.

Gen-ID: 7159

UniProt: Q13625