HTRA2 Antikörper (AA 355-458)

Produktnummer ABIN674214

Dieses Anti-HTRA2-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von HTRA2 in WB, ELISA, IF (p), IF (cc), IHC (p) und IHC (fro). Geeignet für Human, Maus und Ratte.

Kurzübersicht für HTRA2 Antikörper (AA 355-458) (ABIN674214)

Target: HTRA2 (HtrA Serine Peptidase 2 (HTRA2))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HTRA2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Produktdetails anti-HTRA2 Antikörper

Bindungsspezifität: AA 355-458

Kreuzreaktivität: Human, Maus, Ratte

Homologie: Dog,Cow,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human HtrA2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu HTRA2

Target: HTRA2 (HtrA Serine Peptidase 2 (HTRA2))

Andere Bezeichnung: HtrA2/Omi

Hintergrund:

Synonyms: High temperature requirement protein a2, HTRA 2, HtrA like serine protease, HtrA serine peptidase 2, Omi stress regulated endoprotease, PARK 13, PARK13, Protease serine 25, PRSS 25, PRSS25, Serine protease 25, Serine protease HTRA2 mitochondrial, HtrA2, HTRA2_HUMAN, mitochondrial, Omi stress-regulated endoprotease, Serine protease HTRA2, Serine proteinase OMI, Serine protease htra2 mitochondrial precursor, Serine protease omi.

Background: Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins(also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Isoform 2 seems to be proteolytically inactive. [CATALYTIC ACTIVITY] Cleavage of non-polar aliphatic amino-acids at the P1 position, with a preference for Val, Ile and Met. At the P2 and P3 positions, Arg is selected most strongly with a secondary preference for other hydrophilic residues. [SUBUNIT] Homotrimer. Interacts with MXI2. The mature protein, but not the precursor, binds to BIRC2, BIRC3 and XIAP.

Gen-ID: 27429

UniProt: O43464

Pathways: Positive Regulation of Endopeptidase Activity