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TIMM17A Antikörper

Dieses Anti-TIMM17A-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von TIMM17A in WB, IHC, IF, IHC (fro), ICC und FACS. Geeignet für Human, Maus und Ratte.
Produktnummer ABIN6719637

Kurzübersicht für TIMM17A Antikörper (ABIN6719637)

Target

Alle TIMM17A Antikörper anzeigen
TIMM17A (Translocase of Inner Mitochondrial Membrane 17 Homolog A (TIMM17A))

Reaktivität

  • 37
  • 16
  • 7
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
Human, Maus, Ratte

Wirt

  • 37
Kaninchen

Klonalität

  • 37
Polyklonal

Konjugat

  • 16
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser TIMM17A Antikörper ist unkonjugiert

Applikation

  • 28
  • 13
  • 13
  • 6
  • 5
  • 5
  • 4
  • 3
  • 1
  • 1
Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC), Flow Cytometry (FACS)
  • Verwendungszweck

    Anti-TIMM17A Antibody Picoband®

    Sequenz

    LFSMIDCSMV QVRGKED

    Kreuzreaktivität (Details)

    No cross-reactivity with other proteins.

    Produktmerkmale

    Anti-TIMM17A Antibody Picoband® (ABIN6719637). Tested in Flow Cytometry, IF, IHC, IHC-F, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

    Aufreinigung

    Immunogen affinity purified.

    Immunogen

    A synthetic peptide corresponding to a sequence in the middle region of human TIMM17A, which shares 88.2% and 82.4% amino acid (aa) sequence identity with mouse and rat TIMM17A, respectively.

    Isotyp

    IgG
  • Applikationshinweise

    Western blot, 0.1-0.5 μg/mL
    Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL
    Immunohistochemistry (Frozen Section), 0.5-1 μg/mL
    Immunocytochemistry/Immunofluorescence, 2 μg/mL
    Flow Cytometry (Fixed), 1-3 μg/1x106 cells
    1. Bauer, M. F., Gempel, K., Reichert, A. S., Rappold, G. A., Lichtner, P., Gerbitz, K. D., Neupert, W., Brunner, M., Hofmann, S. Genetic and structural characterization of the human mitochondrial inner membrane translocase. J. Molec. Biol. 289: 69-82, 1999. 2. Bomer, U., Rassow, J., Zufall, N., Pfanner, N., Meijer, M., Maarse, A. C. The preprotein translocase of the inner mitochondrial membrane: evolutionary conservation of targeting and assembly of Tim17. J. Molec. Biol. 262: 389-395, 1996. 3. Iacovino, M., Granycome, C., Sembongi, H., Bokori-Brown, M., Butow, R. A., Holt, I. J., Bateman, J. M. The conserved translocase Tim17 prevents mitochondrial DNA loss. Hum. Molec. Genet. 18: 65-74, 2009.

    Kommentare

    Tested Species: In-house tested species with positive results. By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH6.0, for 20mins is required for the staining of formalin/paraffin sections. Other applications have not been tested. Optimal dilutions should be determined by end users.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Konzentration

    500 μg/mL

    Buffer

    Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg NaN3.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
  • Target

    TIMM17A (Translocase of Inner Mitochondrial Membrane 17 Homolog A (TIMM17A))

    Andere Bezeichnung

    TIMM17A

    Hintergrund

    Synonyms: Mitochondrial import inner membrane translocase subunit Tim17-A, Inner membrane preprotein translocase Tim17a, TIMM17A, MIMT17, TIM17, TIM17A, TIMM17

    Background: Mitochondrial import inner membrane translocase subunit Tim17-A is an enzyme that in humans is encoded by the TIMM17A gene. It is mapped to 1q32.1. TIM17 is a conserved suppressor of mtDNA instability, and overexpression of TIMM17A can prevent mtDNA loss in a human cellular model of mitochondrial disease.

    Molekulargewicht

    18 kDa

    Gen-ID

    10440

    UniProt

    Q99595
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