TIMM17A Antikörper

Produktnummer ABIN6719637

Dieses Anti-TIMM17A-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von TIMM17A in WB, IHC, IF, IHC (fro), ICC und FACS. Geeignet für Human, Maus und Ratte.

Kurzübersicht für TIMM17A Antikörper (ABIN6719637)

Target: TIMM17A (Translocase of Inner Mitochondrial Membrane 17 Homolog A (TIMM17A))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TIMM17A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC), Flow Cytometry (FACS)

Produktdetails anti-TIMM17A Antikörper

Verwendungszweck: Anti-TIMM17A Antibody Picoband®

Sequenz: LFSMIDCSMV QVRGKED

Kreuzreaktivität (Details): No cross-reactivity with other proteins.

Produktmerkmale: Anti-TIMM17A Antibody Picoband® (ABIN6719637). Tested in Flow Cytometry, IF, IHC, IHC-F, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Aufreinigung: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence in the middle region of human TIMM17A, which shares 88.2% and 82.4% amino acid (aa) sequence identity with mouse and rat TIMM17A, respectively.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, 0.1-0.5 μg/mL
Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL
Immunohistochemistry (Frozen Section), 0.5-1 μg/mL
Immunocytochemistry/Immunofluorescence, 2 μg/mL
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells
1. Bauer, M. F., Gempel, K., Reichert, A. S., Rappold, G. A., Lichtner, P., Gerbitz, K. D., Neupert, W., Brunner, M., Hofmann, S. Genetic and structural characterization of the human mitochondrial inner membrane translocase. J. Molec. Biol. 289: 69-82, 1999. 2. Bomer, U., Rassow, J., Zufall, N., Pfanner, N., Meijer, M., Maarse, A. C. The preprotein translocase of the inner mitochondrial membrane: evolutionary conservation of targeting and assembly of Tim17. J. Molec. Biol. 262: 389-395, 1996. 3. Iacovino, M., Granycome, C., Sembongi, H., Bokori-Brown, M., Butow, R. A., Holt, I. J., Bateman, J. M. The conserved translocase Tim17 prevents mitochondrial DNA loss. Hum. Molec. Genet. 18: 65-74, 2009.

Kommentare:

Tested Species: In-house tested species with positive results. By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH6.0, for 20mins is required for the staining of formalin/paraffin sections. Other applications have not been tested. Optimal dilutions should be determined by end users.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Konzentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na₂HPO₄, 0.05 mg NaN₃.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Details zu TIMM17A

Target: TIMM17A (Translocase of Inner Mitochondrial Membrane 17 Homolog A (TIMM17A))

Andere Bezeichnung: TIMM17A

Hintergrund:

Synonyms: Mitochondrial import inner membrane translocase subunit Tim17-A, Inner membrane preprotein translocase Tim17a, TIMM17A, MIMT17, TIM17, TIM17A, TIMM17

Background: Mitochondrial import inner membrane translocase subunit Tim17-A is an enzyme that in humans is encoded by the TIMM17A gene. It is mapped to 1q32.1. TIM17 is a conserved suppressor of mtDNA instability, and overexpression of TIMM17A can prevent mtDNA loss in a human cellular model of mitochondrial disease.

Molekulargewicht: 18 kDa

Gen-ID: 10440

UniProt: Q99595