ARID2 Antikörper

Produktnummer ABIN6719446

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch ARID2 in WB und IP. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für ARID2 Antikörper (ABIN6719446)

Target: ARID2 (AT Rich Interactive Domain 2 (ARID, RFX-Like) (ARID2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ARID2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP)

Produktdetails anti-ARID2 Antikörper

Verwendungszweck: Anti-ARID2 Antibody Picoband®

Sequenz: DERRKGLAFL DELRQFHHSR

Kreuzreaktivität (Details): No cross-reactivity with other proteins.

Produktmerkmale: Anti-ARID2 Antibody Picoband® (ABIN6719446). Tested in IP, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Aufreinigung: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of human ARID2, identical to the related mouse and rat sequences.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, 0.1-0.5 μg/mL
Immunoprecipitation, 0.5-2 μg/mL
1. Biankin, A. V., Waddell, N., Kassahn, K. S., Gingras, M.-C., Muthuswamy, L. B., Johns, A. L., Miller, D. K., Wilson, P. J., Patch, A.-M., Wu, J., Chang, D. K., Cowley, M. J., and 116 others. Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes. Nature 491: 399-405, 2012. 2. Bramswig, N. C., Caluseriu, O., Ludecke, H.-J., Bolduc, F. V., Noel, N. C. L., Wieland, T., Surowy, H. M., Christen, H.-J., Engels, H., Strom, T. M., Wieczorek, D. Heterozygosity for ARID2 loss-of-function mutations in individuals with a Coffin-Siris syndrome-like phenotype. Hum. Genet. 136: 297-305, 2017.

Kommentare:

Tested Species: In-house tested species with positive results. By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH6.0, for 20mins is required for the staining of formalin/paraffin sections. Other applications have not been tested. Optimal dilutions should be determined by end users.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Details zu ARID2

Target: ARID2 (AT Rich Interactive Domain 2 (ARID, RFX-Like) (ARID2))

Andere Bezeichnung: ARID2

Hintergrund:

Synonyms: AT-rich interactive domain-containing protein 2, ARID domain-containing protein 2, BRG1-associated factor 200, BAF200, Zinc finger protein with activation potential, Zipzap/p200, ARID2, BAF200, KIAA1557

Tissue Specificity: Highly expressed in heart.

Background: AT-rich interactive domain-containing protein 2 (ARID2) is a protein that in humans is encoded by the ARID2 gene. It is mapped to 12q12. This gene encodes a member of the AT-rich interactive domain (ARID)-containing family of DNA-binding proteins. Members of the ARID family have roles in embryonic patterning, cell lineage gene regulation, cell cycle control, transcriptional regulation and chromatin structure modification. This protein functions as a subunit of the polybromo- and BRG1-associated factor or PBAF (SWI/SNF-B) chromatin remodeling complex which facilitates ligand-dependent transcriptional activation by nuclear receptors. Mutations in this gene are associated with hepatocellular carcinomas. A pseudogene of this gene is found on chromosome1.

Molekulargewicht: 245 kDa

Gen-ID: 196528