Cardiac Troponin T2 Antikörper (AA 88-298)

Produktnummer ABIN6719304

Dieses Anti-Cardiac Troponin T2-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von Cardiac Troponin T2 in WB und ELISA. Geeignet für Human, Maus und Ratte.

Kurzübersicht für Cardiac Troponin T2 Antikörper (AA 88-298) (ABIN6719304)

Target: Cardiac Troponin T2 (cTnT) (Cardiac Troponin T (cTnT))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Cardiac Troponin T2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-Cardiac Troponin T2 Antikörper

Bindungsspezifität: AA 88-298

Verwendungszweck: Anti-Cardiac Troponin T/TNNT2 Antibody Picoband®

Kreuzreaktivität (Details): No cross-reactivity with other proteins.

Produktmerkmale: Anti-Cardiac Troponin T/TNNT2 Antibody Picoband® (ABIN6719304). Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Aufreinigung: Immunogen affinity purified.

Immunogen: E. coli-derived human Cardiac Troponin T recombinant protein (Position: K88-K298).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, 0.1-0.5 μg/mL
ELISA, 0.1-0.5 μg/mL
1. Aviles, R. J., Askari, A. T., Lindahl, B., Wallentin, L., Jia, G., Ohman, E. M., Mahaffey, K. W., Newby, L. K., Califf, R. M., Simoons, M. L., Topol, E. J., Lauer, M. S. Troponin T levels in patients with acute coronary syndromes, with or without renal dysfunction. New Eng. J. Med. 346: 2047-2052, 2002. 2. Charlet-B, N., Logan, P., Singh, G., Cooper, T. A. Dynamic antagonism between ETR-3 and PTB regulates cell type-specific alternative splicing. Molec. Cell 9: 649-658, 2002. 3. Du, C.-K., Morimoto, S., Nishii, K., Minakami, R., Ohta, M., Tadano, N., Lu, Q.-W., Wang, Y.-Y., Zhan, D.-Y., Mochizuki, M., Kita, S., Miwa, Y., Takahashi-Yanaga, F., Iwamoto, T., Ohtsuki, I., Sasaguri, T. Knock-in mouse model of dilated cardiomyopathy caused by troponin mutation.Circ. Res. 101: 185-194, 2007.

Kommentare:

Tested Species: In-house tested species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na₂HPO₄, 0.05 mg NaN₃.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Details zu Cardiac Troponin T2

Target: Cardiac Troponin T2 (cTnT) (Cardiac Troponin T (cTnT))

Andere Bezeichnung: TNNT2

Hintergrund:

Synonyms: Troponin T, cardiac muscle, TnTc, Cardiac muscle troponin T, cTnT, TNNT2

Tissue Specificity: Heart. The fetal heart shows a greater expression in the atrium than in the ventricle, while the adult heart shows a greater expression in the ventricle than in the atrium. Isoform 6 predominates in normal adult heart. Isoforms 1, 7 and 8 are expressed in fetal heart. Isoform 7 is also expressed in failing adult heart.

Background: Cardiac muscle troponin T (cTnT), is a protein which in humans is encoded by the TNNT2 gene. It is mapped to 1q32.1. The protein encoded by this gene is the tropomyosin-binding subunit of the troponin complex, which is located on the thin filament of striated muscles and regulates muscle contraction in response to alterations in intracellular calcium ion concentration. Mutations in this gene have been associated with familial hypertrophic cardiomyopathy as well as with dilated cardiomyopathy. Transcripts for this gene undergo alternative splicing that results in many tissue-specific isoforms, however, the full-length nature of some of these variants has not yet been determined.

Molekulargewicht: 43 kDa

Gen-ID: 7139

UniProt: P45379