COMP Antikörper (AA 505-757)

Produktnummer ABIN6719297

Der Kaninchen Polyklonal Anti-COMP-Antikörper wurde für WB, IHC und ELISA validiert. Er ist geeignet, COMP in Proben von Human, Maus und Ratte zu detektieren.

Kurzübersicht für COMP Antikörper (AA 505-757) (ABIN6719297)

Target: COMP (Cartilage Oligomeric Matrix Protein (COMP))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser COMP Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Produktdetails anti-COMP Antikörper

Bindungsspezifität: AA 505-757

Verwendungszweck: Anti-COMP Antibody Picoband®

Kreuzreaktivität (Details): No cross-reactivity with other proteins.

Produktmerkmale: Anti-COMP Antibody Picoband® (ABIN6719297). Tested in ELISA, IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Aufreinigung: Immunogen affinity purified.

Immunogen: E. coli-derived human COMP recombinant protein (Position: Q505-A757).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, 0.1-0.5 μg/mL
Immunohistochemistry (Paraffin-embedded Section), 2-5 μg/mL
ELISA, 0.1-0.5 μg/mL
1. Ballo, R., Briggs, M. D., Cohn, D. H., Knowlton, R. G., Beighton, P. H., Ramesar, R. S. Multiple epiphyseal dysplasia, Ribbing type: a novel point mutation in the COMP gene in a South African family. Am. J. Med. Genet. 68: 396-400, 1997. Note: Erratum: Am. J. Med. Genet. 71: 494 only, 1997. 2. Deere, M., Sanford, T., Ferguson, H. L., Daniels, K., Hecht, J. T. Identification of twelve mutations in cartilage oligomeric matrix protein (COMP) in patients with pseudoachondroplasia. Am. J. Med. Genet. 80: 510-513, 1998.

Kommentare:

Tested Species: In-house tested species with positive results. By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH6.0, for 20mins is required for the staining of formalin/paraffin sections. Other applications have not been tested. Optimal dilutions should be determined by end users.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Details zu COMP

Target: COMP (Cartilage Oligomeric Matrix Protein (COMP))

Andere Bezeichnung: COMP

Hintergrund:

Synonyms: Cartilage oligomeric matrix protein, COMP, Thrombospondin-5, TSP5, COMP

Tissue Specificity: Abundantly expressed in the chondrocyte extracellular matrix, and is also found in bone, tendon, ligament and synovium and blood vessels. Increased amounts are produced during late stages of osteoarthritis in the area adjacent to the main defect.

Background: COMP is a pentameric extracellular matrix protein that catalyzes the assembly of collagens and promotes formation of well-defined fibrils. This gene is mapped to 19q13.32. The protein encoded by this gene is a cytoplasmic enzyme involved in energy homeostasis and is an important serum marker for myocardial infarction. The encoded protein reversibly catalyzes the transfer of phosphate between ATP and various phosphogens such as creatine phosphate. It acts as a homodimer in striated muscle as well as in other tissues, and as a heterodimer with a similar brain isozyme in heart. The encoded protein is a member of the ATP:guanido phosphotransferase protein family.

Molekulargewicht: 83 kDa

Gen-ID: 1311

UniProt: P49747