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TGF beta Receptor 1 (AA 301-400) Antikörper (Cy5)

Reaktivität: Rind (Kuh), Human, Maus, Ratte WB, IF (cc), IF (p) Wirt: Kaninchen Polyclonal Cy5
Produktnummer ABIN671260
  • Target
    TGF beta Receptor 1
    Bindungsspezifität
    AA 301-400
    Reaktivität
    Rind (Kuh), Human, Maus, Ratte
    Wirt
    • 14
    Kaninchen
    Klonalität
    • 14
    Polyklonal
    Konjugat
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cy5
    Applikation
    • 14
    • 12
    • 12
    • 3
    • 3
    • 3
    Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Kreuzreaktivität
    Rind (Kuh), Human, Maus, Ratte
    Homologie
    Cow
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human TGF-beta R1
    Isotyp
    IgG
  • Applikationshinweise
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Haltbarkeit
    12 months
  • Target
    TGF beta Receptor 1
    Synonyme
    AAT5 antikoerper, ACVRLK4 antikoerper, ALK-5 antikoerper, ALK5 antikoerper, LDS1A antikoerper, LDS2A antikoerper, MSSE antikoerper, SKR4 antikoerper, TGFR-1 antikoerper, AU017191 antikoerper, Alk-5 antikoerper, TbetaR-I antikoerper, TbetaRI antikoerper, Alk5 antikoerper, Skr4 antikoerper, Tgfr-1 antikoerper, tbetaR-I antikoerper, transforming growth factor beta receptor 1 antikoerper, transforming growth factor, beta receptor I antikoerper, transforming growth factor, beta receptor 1 antikoerper, TGFBR1 antikoerper, Tgfbr1 antikoerper
    Hintergrund

    Synonyms: AAT5, ALK5, ESS1, LDS1, MSSE, SKR4, ALK-5, LDS1A, LDS2A, TGFR-1, ACVRLK4, TGF-beta receptor type-1, Activin A receptor type II-like protein kinase of 53kD, Activin receptor-like kinase 5, Serine/threonine-protein kinase receptor R4, TGF-beta type I receptor, Transforming growth factor-beta receptor type I, TGF-beta receptor type I, TbetaR-I, TGFBR1

    Background: Transmembrane serine/threonine kinase forming with the TGF-beta type II serine/threonine kinase receptor, TGFBR2, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 Molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFBR1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways. For instance, TGFBR1 induces TRAF6 autoubiquitination which in turn results in MAP3K7 ubiquitination and activation to trigger apoptosis. Also regulates epithelial to mesenchymal transition through a SMAD-independent signaling pathway through PARD6A phosphorylation and activation.

    Gen-ID
    7046
    UniProt
    P36897
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