MMP13 Antikörper (AA 201-300)

Produktnummer ABIN670341

Dieses Anti-MMP13-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von MMP13 in WB, ELISA, IHC (p) und IHC (fro). Geeignet für Human, Maus und Ratte. Dieses Primary Antibody wurde in 7+ Publikationen zitiert.

Kurzübersicht für MMP13 Antikörper (AA 201-300) (ABIN670341)

Target: MMP13 (Matrix Metallopeptidase 13 (Collagenase 3) (MMP13))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MMP13 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Produktdetails anti-MMP13 Antikörper

Bindungsspezifität: AA 201-300

Kreuzreaktivität: Human, Maus, Ratte

Homologie: Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human MMP13

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Referenzen für anti-MMP13 Antikörper (ABIN670341)

Xiao, Li, Zhang, Xu, Zhang: "Pannexin 3 activates P2X7 receptor to mediate inflammation and cartilage matrix degradation in temporomandibular joint osteoarthritis." in: Cell biology international, Vol. 47, Issue 7, pp. 1183-1197, (2023) (PubMed).

Cao, Bai, Liu, Dou, Li, Xiang, Zhao, Xie, Xiang, Dong: "Hypertrophic differentiation of mesenchymal stem cells is suppressed by xanthotoxin via the p38‑MAPK/HDAC4 pathway." in: Molecular medicine reports, Vol. 16, Issue 3, pp. 2740-2746, (2018) (PubMed).

Yang, Lu, Guo: "Platelet-rich plasma protects rat chondrocytes from interleukin-1β-induced apoptosis." in: Molecular medicine reports, Vol. 14, Issue 5, pp. 4075-4082, (2016) (PubMed).

Ou, Wang, Liu, Li, Yeh, Qi, Chang: "Tumor microenvironment B cells increase bladder cancer metastasis via modulation of the IL-8/androgen receptor (AR)/MMPs signals." in: Oncotarget, Vol. 6, Issue 28, pp. 26065-78, (2016) (PubMed).

Ma, Wu, Wang, Wang, Wu, Zhu, Zhao: "Effects of chronic sleep deprivation on the extracellular signal-regulated kinase pathway in the temporomandibular joint of rats." in: PLoS ONE, Vol. 9, Issue 9, pp. e107544, (2014) (PubMed).

Luo, Zhang, Wang, Hu, Song, Su, Zhang: "Alendronate retards the progression of lumbar intervertebral disc degeneration in ovariectomized rats." in: Bone, Vol. 55, Issue 2, pp. 439-48, (2013) (PubMed).

Zhang, Li, Zhang, Fu, Cui: "Hydrogen sulfide suppresses the expression of MMP-8, MMP-13, and TIMP-1 in left ventricles of rats with cardiac volume overload." in: Acta pharmacologica Sinica, Vol. 34, Issue 10, pp. 1301-9, (2013) (PubMed).

Details zu MMP13

Target: MMP13 (Matrix Metallopeptidase 13 (Collagenase 3) (MMP13))

Andere Bezeichnung: MMP-13

Hintergrund:

Synonyms: CLG3, MANDP1, MMP-13, Collagenase 3, Matrix metalloproteinase-13, MMP13

Background: Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CTGF. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal embryonic bone development and ossification. Plays a role in the healing of bone fractures via endochondral ossification. Plays a role in wound healing, probably by a mechanism that involves proteolytic activation of TGFB1 and degradation of CTGF. Plays a role in keratinocyte migration during wound healing. May play a role in cell migration and in tumor cell invasion.

Gen-ID: 4322

UniProt: P45452