WNK4 Antikörper (AA 351-450) (HRP)

Produktnummer ABIN668535

This anti-WNK4 antibody (ABIN668535) is a Rabbit Polyclonal antibody detecting WNK4 in ELISA, WB. Suitable for Mouse.

Kurzübersicht für WNK4 Antikörper (AA 351-450) (HRP) (ABIN668535)

Target: WNK4 (WNK Lysine Deficient Protein Kinase 4 (WNK4))

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser WNK4 Antikörper ist konjugiert mit HRP

Applikation: ELISA, Western Blotting (WB)

Produktdetails anti-WNK4 Antikörper (HRP)

Bindungsspezifität: AA 351-450

Kreuzreaktivität: Maus

Homologie: Human,Rat

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human WNK4

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handhabung: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu WNK4

Target: WNK4 (WNK Lysine Deficient Protein Kinase 4 (WNK4))

Andere Bezeichnung: WNK4

Hintergrund:

Synonyms: PHA 2B, PHA2B, PRKWNK 4, PRKWNK4, Protein kinase lysine deficient 4, Protein kinase with no lysine 4, Serine/threonine protein kinase WNK4, WNK lysine deficient protein kinase 4, WNK4_HUMAN.

Background: Regulates the activity of the thiazide-sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation which appears to prevent membrane trafficking of SLC12A3. Also inhibits the renal K(+)channel, KCNJ1, via a kinase-independent mechanism by which it induces clearance of the protein from the cell surface by clathrin-dependent endocytosis. WNK4 appears to act as a molecular switch that can vary the balance between NaCl reabsorption and K(+)secretion to maintain integrated homeostasis.

Gen-ID: 65266