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WNK4 Antikörper (Cy5)

This anti-WNK4 antibody (ABIN668530) is a Rabbit Polyclonal antibody detecting WNK4 in WB. Suitable for Human, Mouse, Rat.
Produktnummer ABIN668530

Kurzübersicht für WNK4 Antikörper (Cy5) (ABIN668530)

Target

Alle WNK4 Antikörper anzeigen
WNK4 (WNK Lysine Deficient Protein Kinase 4 (WNK4))

Reaktivität

  • 40
  • 31
  • 26
  • 4
  • 1
Human, Maus, Ratte

Wirt

  • 41
  • 2
Kaninchen

Klonalität

  • 41
  • 2
Polyklonal

Konjugat

  • 13
  • 5
  • 3
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser WNK4 Antikörper ist konjugiert mit Cy5

Applikation

  • 21
  • 20
  • 6
  • 1
Western Blotting (WB)
  • Kreuzreaktivität

    Maus

    Homologie

    Human,Rat

    Aufreinigung

    Purified by Protein A.

    Immunogen

    KLH conjugated synthetic peptide derived from human WNK4

    Isotyp

    IgG
  • Applikationshinweise

    IF(IHC-P) 1:50-200

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    1 μg/μL

    Buffer

    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

    Haltbarkeit

    12 months
  • Target

    WNK4 (WNK Lysine Deficient Protein Kinase 4 (WNK4))

    Andere Bezeichnung

    WNK4

    Hintergrund

    Synonyms: PHA 2B, PHA2B, PRKWNK 4, PRKWNK4, Protein kinase lysine deficient 4, Protein kinase with no lysine 4, Serine/threonine protein kinase WNK4, WNK lysine deficient protein kinase 4, WNK4_HUMAN.

    Background: Regulates the activity of the thiazide-sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation which appears to prevent membrane trafficking of SLC12A3. Also inhibits the renal K(+)channel, KCNJ1, via a kinase-independent mechanism by which it induces clearance of the protein from the cell surface by clathrin-dependent endocytosis. WNK4 appears to act as a molecular switch that can vary the balance between NaCl reabsorption and K(+)secretion to maintain integrated homeostasis.

    Gen-ID

    65266
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