MOG Antikörper (PE-Cy7)

Produktnummer ABIN668494

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch MOG in FACS. Er zeigt eine Reaktivität gegenüber Human, Maus, Ratte, Schwein und Meerschweinchen.

Kurzübersicht für MOG Antikörper (PE-Cy7) (ABIN668494)

Target: MOG (Myelin Oligodendrocyte Glycoprotein (MOG))

Reaktivität: Human, Maus, Ratte, Schwein, Meerschweinchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MOG Antikörper ist konjugiert mit PE-Cy7

Applikation: Flow Cytometry (FACS)

Produktdetails anti-MOG Antikörper (PE-Cy7)

Spezifität: Excitation / Emission Wavelengths: 480,565,743nm/767nm

Kreuzreaktivität: Ratte (Rattus), Schwein, Meerschweinchen

Aufreinigung: purified by Protein A

Immunogen: KLH conjugated synthetic peptide derived from human MOG

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: FCM(1:100-500)
Optimal working dilution should be determined by the investigator.

Kommentare:

Excitation / Emission wavelength: 496,565nm / 774nm

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 µg/µL

Buffer: Aqueous buffered solution containing 100 µg/mL BSA, 50 % glycerol and 0.09 % Gentamicin.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store at 4 °C for 12 months

Haltbarkeit: 12 months

Details zu MOG

Target: MOG (Myelin Oligodendrocyte Glycoprotein (MOG))

Andere Bezeichnung: MOG

Hintergrund: Myelin oligodendrocyte glycoprotein (MOG) is a key CNS-specific autoantigen for primary demyelination in multiple sclerosis. Although the disease-inducing role of MOG has been established, its precise function in the CNS remains obscure. MOG is a type I integral membrane protein possessing a single extracellular Ig variable domain (Ig-V) (3, 13, 14). The amino acid sequence of MOG is highly conserved among animal species (>90%), indicative of an important biological function. MOG is specifically expressed in the CNS on the outermost lamellae of the myelin sheath as well as the cell body and processes of oligodendrocytes. The developmentally late expression of MOG correlates with the later stages of myelinogenesis, suggesting that MOG has a role in the completion, compaction, and/or maintenance of myelin, further suggesting that MOG has an adhesive function within the CNS . Consistent with MOG's possible adhesive role in the CNS, a homodimeric form of MOG has not only been observed after isolation from the CNS but has additionally been observed in situ.

Molekulargewicht: 28kDa

Gen-ID: 4340