GABRG2 Antikörper

Produktnummer ABIN6658275

Hersteller Produkt- Nr.: 112-401-c81

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch GABRG2 in WB und IHC. Er zeigt eine Reaktivität gegenüber Ratte.

Kurzübersicht für GABRG2 Antikörper (ABIN6658275)

Target: GABRG2 (gamma-aminobutyric Acid (GABA) A Receptor, gamma 2 (GABRG2))

Reaktivität: Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GABRG2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-GABRG2 Antikörper

Hersteller Produkt- Nr.: 112-401-c81

Hersteller: Rockland

Verwendungszweck: GABA(A) Receptor gamma 2 Antibody

Kreuzreaktivität (Details): Anti-GABA(A) Receptor gamma 2 Antibody is directed against rat GABA(A) Receptor gamma 2.

Aufreinigung: The antibody was prepared from monospecific neat serum.

Immunogen: Anti-GABA(A) Receptor gamma 2 Antibody was produced by repeated immunizations with rat GABA(A) Receptor gamma 2- Synthetic peptide corresponding to amino acid residues specific to the gamma 2 subunit.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

Immunohistochemistry_Dilution: 1:400

Western_Blot_Dilution: 1:1000

Kommentare:

Anti-GABA(A) Receptor gamma 2 (Rabbit) antibody has been tested in Western Blotting and IHC. Expect a band of approximately 46kDa in size corresponding γ2-subunit of the GABAA receptor in Western blots of rat brain extracts. Specific conditions should by optimized by the end user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store vial at -20° C prior to opening.  This product is stable at 4° C as an undiluted liquid.  For extended storage, aliquot contents and freeze at -20° C or below.  Avoid cycles of freezing and thawing. Dilute only prior to immediate use.

Haltbarkeit: 12 months

Details zu GABRG2

Target: GABRG2 (gamma-aminobutyric Acid (GABA) A Receptor, gamma 2 (GABRG2))

Andere Bezeichnung: GABA(A) Receptor gamma 2

Hintergrund:

Synonyms: rabbit anti-GABA(A) Receptor gamma 2 Antibody, Gamma-aminobutyric acid receptor subunit gamma-2, GABA(A) receptor subunit gamma-2, Gabrg2

Background: Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl- channel associated with the GABAA receptor (GABAA-R) sub-type. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and substance abuse. The GABAA-R is a multimeric subunit complex. To date six αs, four βs and four γs, plus alternative splicing variants of some of these subunits, have been identified. Injection in oocytes or mammalian cell lines of cRNA coding for α- and β-subunits results in the expression of functional GABAA-Rs sensitive to GABA. However, co-expression of a γ-subunit is required for benzodiazepine modulation. The various effects of the benzodiazepines in brain may also be mediated via different α-subunits of the receptor. Phosphorylation of β-subunits of the receptor has been shown to modulate GABAA-R function. Anti-GABA(A) Receptor gamma 2 antibody is ideal for investigators involved in Neuroscience.

Gene Name: GABRG2

Gen-ID: 29709

NCBI Accession: NP_899156