Synaptojanin 1 Antikörper (C-Term)

Kurzübersicht für Synaptojanin 1 Antikörper (C-Term) (ABIN6658254)
Target
Alle Synaptojanin 1 (SYNJ1) Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
Klon
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Bindungsspezifität
- C-Term
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Hersteller Produkt- Nr.
- 212-301-e35
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Hersteller
- Rockland
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Verwendungszweck
- Synaptojanin 1 Antibody
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Kreuzreaktivität (Details)
- Anti-Synaptojanin 1 Monoclonal Antibody is directed against rat synaptojanin 1
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Aufreinigung
- .Synaptojanin 1 antibody was Protein G purified from cell culture supernatant.
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Immunogen
- Anti-Synaptojanin 1 Monoclonal Antibody was produced in mouse by repeated immunizations with recombinant protein from the C-terminal region of rat synaptojanin 1.
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Isotyp
- IgG1
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Applikationshinweise
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Immunohistochemistry_Dilution: 1:1000
Western_Blot_Dilution: 1:1000
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Kommentare
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Anti-Synaptojanin 1 antibody is tested for use in Western Blotting and IHC. Expect a band of approximately 145 kDa in size corresponding to synaptojanin I proteins of rat brain extracts. Researchers should determine optimal titers for applications that are not stated below.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Buffer
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Buffer: 0.01 M HEPES, 0.15 M Sodium Chloride, pH 7.5
Stabilizer: 0.1 mg/mL Bovine Serum Albumin (BSA) - IgG and Protease free, 50 % (v/v) Glycerol
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Lagerung
- 4 °C,-20 °C
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Informationen zur Lagerung
- Store vial at -20° C prior to opening. This product is stable at 4° C as an undiluted liquid. For extended storage, aliquot contents and freeze at -20° C or below. Avoid cycles of freezing and thawing. Dilute only prior to immediate use.
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Haltbarkeit
- 12 months
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- Synaptojanin 1 (SYNJ1)
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Andere Bezeichnung
- Synaptojanin 1
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Hintergrund
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Synonyms: mouse anti-Synaptojanin 1 Antibody, Synaptic inositol-1,4,5-trisphosphate 5-phosphatase 1
Background: Synaptojanin 1 Monoclonal Antibody detects Synaptojanin 1, which is a phosphatidylinositol phosphatase involved in clathrin-mediated endocytosis of synaptic vesicles. Synaptojanin 1 has two alternatively spliced isoforms, one that is ~ 145 kDA and is exclusively expressed in neurons, and the other ~ 170 kDa which is expressed in non-neuronal, peripheral tissues. The gene which encodes Synaptojanin 1, SYNJ1, has been mapped to chromosome 21 thus making it a candidate for involvement in Down's syndrome (DS). It has recently been demonstrated that Ts65Dn mice (the most commonly used model of DS) have altered phosphatidylinositol-4,5-bisphosphate metabolism. This defect is rescued by restoring SYNJ1 to disomy in the Ts65Dn mice.
Gene Name: SYNJ1
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Gen-ID
- 85238
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UniProt
- Q62910
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Pathways
- Inositol Metabolic Process, Synaptic Vesicle Exocytosis
Target
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