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Synaptojanin 1 Antikörper (C-Term)

Dieses Maus Monoklonal-Antikörper erkennt spezifisch Synaptojanin 1 in WB und IHC. Er zeigt eine Reaktivität gegenüber Ratte.
Rockland
Produktnummer ABIN6658254
Hersteller Produkt- Nr.: 212-301-e35

Kurzübersicht für Synaptojanin 1 Antikörper (C-Term) (ABIN6658254)

Target

Alle Synaptojanin 1 (SYNJ1) Antikörper anzeigen
Synaptojanin 1 (SYNJ1)

Reaktivität

  • 23
  • 19
  • 6
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
Ratte

Wirt

  • 33
  • 6
Maus

Klonalität

  • 34
  • 5
Monoklonal

Konjugat

  • 21
  • 3
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser Synaptojanin 1 Antikörper ist unkonjugiert

Applikation

  • 20
  • 14
  • 13
  • 13
  • 6
  • 4
  • 3
  • 3
  • 3
Western Blotting (WB), Immunohistochemistry (IHC)

Klon

5H1
  • Bindungsspezifität

    • 15
    • 6
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term

    Hersteller Produkt- Nr.

    212-301-e35

    Hersteller

    Rockland

    Verwendungszweck

    Synaptojanin 1 Antibody

    Kreuzreaktivität (Details)

    Anti-Synaptojanin 1 Monoclonal Antibody is directed against rat synaptojanin 1

    Aufreinigung

    .Synaptojanin 1 antibody was Protein G purified from cell culture supernatant.

    Immunogen

    Anti-Synaptojanin 1 Monoclonal Antibody was produced in mouse by repeated immunizations with recombinant protein from the C-terminal region of rat synaptojanin 1.

    Isotyp

    IgG1
  • Applikationshinweise

    Immunohistochemistry_Dilution: 1:1000

    Western_Blot_Dilution: 1:1000

    Kommentare

    Anti-Synaptojanin 1 antibody is tested for use in Western Blotting and IHC. Expect a band of approximately 145 kDa in size corresponding to synaptojanin I proteins of rat brain extracts. Researchers should determine optimal titers for applications that are not stated below.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Buffer

    Buffer: 0.01 M HEPES, 0.15 M Sodium Chloride, pH 7.5

    Stabilizer: 0.1 mg/mL Bovine Serum Albumin (BSA) - IgG and Protease free, 50 % (v/v) Glycerol

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Store vial at -20° C prior to opening.  This product is stable at 4° C as an undiluted liquid.  For extended storage, aliquot contents and freeze at -20° C or below.  Avoid cycles of freezing and thawing. Dilute only prior to immediate use.

    Haltbarkeit

    12 months
  • Target

    Synaptojanin 1 (SYNJ1)

    Andere Bezeichnung

    Synaptojanin 1

    Hintergrund

    Synonyms: mouse anti-Synaptojanin 1 Antibody, Synaptic inositol-1,4,5-trisphosphate 5-phosphatase 1

    Background: Synaptojanin 1 Monoclonal Antibody detects Synaptojanin 1, which is a phosphatidylinositol phosphatase involved in clathrin-mediated endocytosis of synaptic vesicles. Synaptojanin 1 has two alternatively spliced isoforms, one that is ~ 145 kDA and is exclusively expressed in neurons, and the other ~ 170 kDa which is expressed in non-neuronal, peripheral tissues. The gene which encodes Synaptojanin 1, SYNJ1, has been mapped to chromosome 21 thus making it a candidate for involvement in Down's syndrome (DS). It has recently been demonstrated that Ts65Dn mice (the most commonly used model of DS) have altered phosphatidylinositol-4,5-bisphosphate metabolism. This defect is rescued by restoring SYNJ1 to disomy in the Ts65Dn mice.

    Gene Name: SYNJ1

    Gen-ID

    85238

    UniProt

    Q62910

    Pathways

    Inositol Metabolic Process, Synaptic Vesicle Exocytosis
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