GABRB1 Antikörper (Cytoplasmic Loop)

Produktnummer ABIN6658240

Hersteller Produkt- Nr.: 612-401-d49

Der Kaninchen Polyklonal Anti-GABRB1-Antikörper wurde für WB validiert. Er ist geeignet, GABRB1 in Proben von Ratte zu detektieren.

Kurzübersicht für GABRB1 Antikörper (Cytoplasmic Loop) (ABIN6658240)

Target: GABRB1 (gamma-aminobutyric Acid (GABA) A Receptor, Subunit beta 1 (GABRB1))

Reaktivität: Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GABRB1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-GABRB1 Antikörper

Bindungsspezifität: Cytoplasmic Loop

Hersteller Produkt- Nr.: 612-401-d49

Hersteller: Rockland

Verwendungszweck: GABA(A) Receptor beta 1 Antibody

Kreuzreaktivität (Details): Anti-GABA(A) Receptor beta 1 Antibody is directed against rat GABA(A) Receptor beta 1.

Aufreinigung: The antibody was affinity purified from monospecific antiserum by immunoaffinity purification.

Immunogen: Anti-GABA(A) Receptor beta 1 Antibody was produced by repeated immunizations with recombinant fusion proteins from the cytoplasmic loop of the beta 1 subunit of rat GABAA.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optional[Neutralization_Dilution]: 1:1000

Kommentare:

Anti-GABA(A) Receptor beta 1 (Rabbit) antibody is tested for use in Western Blotting. Specific conditions for reactivity should be optimized by the end user. Expect a band of approximately 55 kDa in size corresponding to the beta 1 subunit of the GABA(A) receptor in the appropriate cell lysate or extract.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer:

Buffer: 0.01 M HEPES, 0.15 M Sodium Chloride, pH 7.5

Stabilizer: 0.1 mg/mL Bovine Serum Albumin (BSA) - IgG and Protease free, 50 % (v/v) Glycerol

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store vial at -20° C prior to opening.  This product is stable at 4° C as an undiluted liquid.  For extended storage, aliquot contents and freeze at -20° C or below.  Avoid cycles of freezing and thawing. Dilute only prior to immediate use.

Haltbarkeit: 12 months

Details zu GABRB1

Target: GABRB1 (gamma-aminobutyric Acid (GABA) A Receptor, Subunit beta 1 (GABRB1))

Andere Bezeichnung: GABA(A) Receptor beta 1

Hintergrund:

Synonyms: Gamma-aminobutyric acid receptor subunit beta-1, GABA(A) receptor subunit beta-1, GABA(A) receptor subunit ß-1,

Background: Anti-GABA(A) Receptor beta 1 Antibody detects GABA(A) Receptor beta 1. Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl- channel associated with the GABAA receptor (GABAA-R) subtype. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and substance abuse. The GABAA-R is a multimeric subunit complex. To date six alphas, four betas and four gammas, plus alternative splicing variants of some of these subunits, have been identified. Injection in oocytes or mammalian cell lines of cRNA coding for alpha- and beta-subunits results in the expression of functional GABAA-Rs sensitive to GABA. However, coexpression of a gamma- subunit is required for benzodiazepine modulation. The various effects of the benzodiazepines in brain may also be mediated via different α-subunits of the receptor. GABA(A) receptor beta 1 antibody is ideal for investigators involved in Neuroscience.

Gene Name: GABRB1

Gen-ID: 25450

UniProt: P15431