GABRA3 Antikörper (N-Term)

Produktnummer ABIN6658232

Hersteller Produkt- Nr.: 600-401-d46

Dieses Anti-GABRA3-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von GABRA3 in WB und IHC. Geeignet für Ratte.

Kurzübersicht für GABRA3 Antikörper (N-Term) (ABIN6658232)

Target: GABRA3 (gamma-aminobutyric Acid (GABA) A Receptor, alpha 3 (GABRA3))

Reaktivität: Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GABRA3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-GABRA3 Antikörper

Bindungsspezifität: N-Term

Hersteller Produkt- Nr.: 600-401-d46

Hersteller: Rockland

Verwendungszweck: GABA(A) Receptor alpha 3 Antibody

Kreuzreaktivität (Details): Anti-GABA(A) Receptor alpha 3 antibody is directed against human GABA(A) Receptor alpha 3.

Aufreinigung: The antibody was affinity purified from monospecific antibodies by immunoaffinity purification.

Immunogen: Anti-GABA(A) Receptor alpha 3 Antibody was produced by repeated immunizations with a synthetic peptide from the N-terminal region of the alpha 3 subunit of rat GABAA.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

Immunohistochemistry_Dilution: 1:100

Western_Blot_Dilution: 1:1000

Kommentare:

Anti-GABA(A) Receptor alpha 3 (Rabbit) antibody is tested for use in Western Blotting and IHC. Specific conditions for reactivity should be optimized by the end user. Expect a band of approximately 51 kDa in size corresponding to the alpha 3 subunit of the GABA(A) receptor in the appropriate cell lysate or extract.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer:

Buffer: 0.01 M HEPES, 0.15 M Sodium Chloride, pH 7.5

Stabilizer: 0.1 mg/mL Bovine Serum Albumin (BSA) - IgG and Protease free, 50 % (v/v) Glycerol

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store vial at -20° C prior to opening.  This product is stable at 4° C as an undiluted liquid.  For extended storage, aliquot contents and freeze at -20° C or below.  Avoid cycles of freezing and thawing. Dilute only prior to immediate use.

Haltbarkeit: 12 months

Details zu GABRA3

Target: GABRA3 (gamma-aminobutyric Acid (GABA) A Receptor, alpha 3 (GABRA3))

Andere Bezeichnung: GABA(A) Receptor alpha 3

Hintergrund:

Synonyms: Gamma-aminobutyric acid receptor subunit alpha-3, GABA(A) receptor subunit alpha-3

Background: GABA(A) Receptor alpha 3 antibody detects GABA(A) Receptor alpha 3. Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl- channel associated with the GABAA receptor (GABAA-R) subtype. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and substance abuse. The GABAA-R is a multimeric subunit complex. To date six αs, four βs and four γs, plus alternative splicing variants of some of these subunits, have been identified. Injection in oocytes or mammalian cell lines of cRNA coding for α- and β-subunits results in the expression of functional GABAA-Rs sensitive to GABA. However, coexpression of a γ-subunit is required for benzodiazepine modulation. The various effects of the benzodiazepines in brain may also be mediated via different α-subunits of the receptor. Anti-GABA(A) Receptor alpha 3 Antibody is ideal for investigators involved in Neuroscience.

Gene Name: GABRA3

Gen-ID: 24947

NCBI Accession: NP_058765

UniProt: P20236