GABRG2 Antikörper (pSer327)

Produktnummer ABIN6658228

Hersteller Produkt- Nr.: 612-401-d52

Der Kaninchen Polyklonal Anti-GABRG2-Antikörper wurde für WB validiert. Er ist geeignet, GABRG2 in Proben von Ratte zu detektieren.

Kurzübersicht für GABRG2 Antikörper (pSer327) (ABIN6658228)

Target: GABRG2 (gamma-aminobutyric Acid (GABA) A Receptor, gamma 2 (GABRG2))

Reaktivität: Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GABRG2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-GABRG2 Antikörper

Bindungsspezifität: pSer327

Hersteller Produkt- Nr.: 612-401-d52

Hersteller: Rockland

Verwendungszweck: GABA(A) Receptor gamma 2 phospho S327 Antibody

Kreuzreaktivität (Details): Anti-GABA(A) Receptor gamma 2 pS327 Antibody is directed against rat phosphorylated GABA(A) Receptor gamma 2.

Aufreinigung: The antibody was affinity purified from monospecific antiserum by immunoaffinity purification.

Immunogen: Anti-GABA(A) Receptor gamma 2 pS327 Antibody was produced by repeated immunizations with synthetic phospho-peptide corresponding to amino acid residues surrounding Ser327 of rat GABAA receptor gamma 2.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optional[Neutralization_Dilution]: 1:1000

Kommentare:

Anti-GABA(A) Receptor gamma 2 pS327 (Rabbit) antibody is tested for use in Western Blotting. Specific conditions for reactivity should be optimized by the end user. Expect a band of approximately 45 kDa in size corresponding to GABA(A) receptor gamma 2 subunit phosphorylated at Ser327 in the appropriate cell lysate or extract.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer:

Buffer: 0.01 M HEPES, 0.15 M Sodium Chloride, pH 7.5

Stabilizer: 0.1 mg/mL Bovine Serum Albumin (BSA) - IgG and Protease free, 50 % (v/v) Glycerol

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store vial at -20° C prior to opening.  This product is stable at 4° C as an undiluted liquid.  For extended storage, aliquot contents and freeze at -20° C or below.  Avoid cycles of freezing and thawing. Dilute only prior to immediate use.

Haltbarkeit: 12 months

Details zu GABRG2

Target: GABRG2 (gamma-aminobutyric Acid (GABA) A Receptor, gamma 2 (GABRG2))

Andere Bezeichnung: GABA(A) Receptor gamma 2

Hintergrund:

Synonyms: Gamma-aminobutyric acid receptor subunit gamma-2, GABA(A) receptor subunit gamma-2, Gabrg2

Background: Anti-GABA(A) Receptor gamma 2 pS327 Antibody detects phosphorylated GABA(A) Receptor gamma 2. Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system. There are two major classes of GABA receptors: the GABAA and the GABAB subtype of receptors. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and sub-stance abuse. The GABAA-R is a multimeric subunit complex. To date six alphas, four betas and four gammas, plus alternative splicing variants of some of these subunits, have been identified. Injection in oocytes or mammalian cell lines of cRNA coding for alpha- and beta-subunits results in the expression of functional GABAA-Rs sensitive to GABA. However, coexpression of a gamma- subunit is required for benzodiazepine modulation. It has recently been suggested that PKC? regulates the sensitivity of GABAA alpha1-beta2-gamma2 receptors to ethanol and benzodiazepines through phosphorylation of serine 327 in the large intracellular loop of gamma2. GABA(A) Receptor gamma2 pS327 antibody is ideal for investigators involved in Neuroscience.

Gene Name: GABRG2

Gen-ID: 29709, 8393403

UniProt: P18508