GABRA6 Antikörper

Produktnummer ABIN6658222

Hersteller Produkt- Nr.: 100-401-d48

Der Kaninchen Polyklonal Anti-GABRA6-Antikörper wurde für WB validiert. Er ist geeignet, GABRA6 in Proben von Ratte zu detektieren.

Kurzübersicht für GABRA6 Antikörper (ABIN6658222)

Target: GABRA6 (gamma-aminobutyric Acid (GABA) A Receptor, alpha 6 (GABRA6))

Reaktivität: Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GABRA6 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-GABRA6 Antikörper

Hersteller Produkt- Nr.: 100-401-d48

Hersteller: Rockland

Verwendungszweck: GABAA Receptor alpha 6 Antibody

Kreuzreaktivität (Details): Anti-GABA(A) Receptor alpha 6 Antibody is directed against rat GABA(A) Receptor alpha 6.

Aufreinigung: The antibody was prepared from monospecific neat serum.

Immunogen: Anti-GABA(A) Receptor a 6 Antibody was produced by repeated immunizations with rat GABA(A) receptor alpha 6- Synthetic peptide corresponding to amino acid specific to the alpha 6 subunit.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optional[Neutralization_Dilution]: 1:1000

Kommentare:

Anti-GABA(A) Receptor alpha 6 (Rabbit) antibody has been tested in Western Blotting. Specific conditions for reactivity should be optimized by the end user. Expect a band of approximately 57 kDa in size corresponding to the alpha 6 subunit of the GABA(A) receptor in the appropriate cell lysate or extract.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store vial at -20° C prior to opening.  This product is stable at 4° C as an undiluted liquid.  For extended storage, aliquot contents and freeze at -20° C or below.  Avoid cycles of freezing and thawing. Dilute only prior to immediate use.

Haltbarkeit: 12 months

Details zu GABRA6

Target: GABRA6 (gamma-aminobutyric Acid (GABA) A Receptor, alpha 6 (GABRA6))

Andere Bezeichnung: GABA(A) Receptor alpha 6

Hintergrund:

Synonyms: Gamma-aminobutyric acid receptor subunit alpha-6, GABA(A) receptor subunit alpha-6

Background: Anti-GABA(A) Receptor alpha 6 Antibody detects GABA(A) Receptor alpha 6. Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl- channel associated with the GABAA receptor (GABAA-R) subtype. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and substance abuse. The GABAA-R is a multimeric subunit complex. To date six αs, four βs and four γs, plus alternative splicing variants of some of these subunits, have been identified. Injection in oocytes or mammalian cell lines of cRNA coding for α- and β-subunits results in the expression of functional GABAA-Rs sensitive to GABA. However, coexpression of a γ-subunit is required for benzodiazepine modulation. The various effects of the benzodiazepines in brain may also be mediated via different α-subunits of the receptor. Phosphorylation of β-subunits of the receptor has been shown to modulate GABAA-R function. Anti-GABA(A) receptor alpha 6 antibody is ideal for investigators involved in Neuroscience.

Gene Name: GABRA6

Gen-ID: 29708

NCBI Accession: NP_068613

UniProt: P30191

Pathways: Synaptic Membrane