GRM7 Antikörper (pSer862)

Produktnummer ABIN6658162

Hersteller Produkt- Nr.: 600-401-d78

Der Kaninchen Polyklonal Anti-GRM7-Antikörper wurde für WB validiert. Er ist geeignet, GRM7 in Proben von Ratte zu detektieren.

Kurzübersicht für GRM7 Antikörper (pSer862) (ABIN6658162)

Target: GRM7 (Glutamate Receptor, Metabotropic 7 (GRM7))

Reaktivität: Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GRM7 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-GRM7 Antikörper

Bindungsspezifität: pSer862

Hersteller Produkt- Nr.: 600-401-d78

Hersteller: Rockland

Verwendungszweck: mGluR7 phospho S862 Antibody

Kreuzreaktivität (Details): Anti mGluR7 pS862 antibody is directed against mGluR7 phosphorylated at Ser862.

Aufreinigung: GluR7 antibody is affinity purified from monospecific antiserum by immunoaffinity purification.

Immunogen: Anti-mGluR7 pS862 Antibody was produced in rabbit by repeated immunizations with synthetic phospho-peptide corresponding to amino acid residues surrounding Ser 862 conjugated to KLH.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optional[Neutralization_Dilution]: 1:1000

Kommentare:

Anti-mGluR7 pS862 (Rabbit) antibody is tested for use in Western Blotting. Specific conditions for reactivity should be optimized by the end user. Expect a band of approximately 102 kDa in size corresponding to the mGluR7 protein phosphorylated at Ser862 in the appropriate cell lysate or extract.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer:

Buffer: 0.01 M HEPES, 0.15 M Sodium Chloride, pH 7.5

Stabilizer: 0.1 mg/mL Bovine Serum Albumin (BSA) - IgG and Protease free, 50 % (v/v) Glycerol

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store vial at -20° C prior to opening.  This product is stable at 4° C as an undiluted liquid.  For extended storage, aliquot contents and freeze at -20° C or below.  Avoid cycles of freezing and thawing. Dilute only prior to immediate use.

Haltbarkeit: 12 months

Details zu GRM7

Target: GRM7 (Glutamate Receptor, Metabotropic 7 (GRM7))

Andere Bezeichnung: mGluR7

Hintergrund:

Synonyms: mGluR7, Metabotropic Glutamate Receptor 7

Background: mGluR7 pS862 antibodiy detects mGluR7 when phosphorylated at Ser862. Metabotropic glutamate receptors (mGluRs) are key receptors in the modulation of excitatory synaptic transmission in the central nervous system. They are implicated in many forms of neural plasticity as well as learning and memory and drug abuse. The mGluRs are divided into three groups based on sequence identity and pharmacological properties: group I (mGluR1 and mGluR5) are localized in the perisynaptic region of the postsynaptic membrane, whereas group II (mGlur2 and mGluR3) and group III (mGluR4,6,7 and 8) are localized predominantly at presynaptic terminals. PKC phosphorylation of serine 862 on mGluR7 has been shown to be critical for stabilizing receptor surface expression and promoting binding to the synaptic PDZ-domain-containing protein PICK1. Therefore, mGluR7 pS862 antibody is ideal for investigators involved in neuronal circuitry and more generally in Neuroscience.

Gene Name: GRM7

Gen-ID: 81672

UniProt: P35400

Pathways: Sensory Perception of Sound, cAMP Metabolic Process, Feeding Behaviour