FMR1 Antikörper (pSer499)

Produktnummer ABIN6658159

Hersteller Produkt- Nr.: 600-401-x07

Der Kaninchen Polyklonal Anti-FMR1-Antikörper wurde für WB, IHC und ELISA validiert. Er ist geeignet, FMR1 in Proben von Ratte zu detektieren.

Kurzübersicht für FMR1 Antikörper (pSer499) (ABIN6658159)

Target: FMR1 (Fragile X Mental Retardation 1 (FMR1))

Reaktivität: Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FMR1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Produktdetails anti-FMR1 Antikörper

Bindungsspezifität: pSer499

Hersteller Produkt- Nr.: 600-401-x07

Hersteller: Rockland

Verwendungszweck: FMRP Phospho S499 Antibody

Kreuzreaktivität (Details): Anti-Anti-FMRP pS499 Antibody is directed against FMRP protein phosphorylated at S499.

Aufreinigung: The antibody was prepared from monospecific antiserum by immunoaffinity chromatography using phospho peptide coupled to agarose beads followed by solid phase adsorption(s) against non-phospho peptide and non-specific peptide to remove any unwanted reactivities.

Sterilität: Sterile filtered

Immunogen: Anti-Phospho-Ser499 FMRP Antibody was produced in rabbits by repeated immunizations with a synthetic phospho-peptide corresponding to amino acid residues surrounding Ser499 of rat FRMP conjugated to KLH.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

ELISA_Dilution: 1:10,000

Immunohistochemistry_Dilution: 1:250-1:1000

Western_Blot_Dilution: 1:1000

Kommentare:

Anti-Phospho-Ser499 FMRP Antibody is tested for Western Blot and immunohistochemistry and is specific for the ~71 kDa FMRP protein phosphorylated at Ser499. Immunolabeling of the FMRP protein is completely eliminated by lambda-phosphatase. Specific conditions for reactivity should be optimized by the end user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer:

Buffer: 0.01 M HEPES, 0.15 M Sodium Chloride, pH 7.5

Stabilizer: 0.1 mg/mL Bovine Serum Albumin (BSA) - IgG and Protease free, 50 % (v/v) Glycerol

Preservative: None

Konservierungsmittel: Without preservative

Lagerung: -20 °C

Informationen zur Lagerung: Store vial at -20° C prior to opening in undiluted aliquots. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature.

Haltbarkeit: 12 months

Details zu FMR1

Target: FMR1 (Fragile X Mental Retardation 1 (FMR1))

Andere Bezeichnung: FMRP

Hintergrund:

Synonyms: Fragile X mental retardation protein 1 homolog, FMR-1

Background: Fragile X Mental Retardation Protein (FMRP) is an RNA-binding protein that plays an essential role in cognitive brain function. Mutations in the FMR1 gene, which codes for FMRP, can result in fragile X syndrome, autism, as well as other cognitive deficits. Phosphorylation of the highly conserved Ser499 has been shown to trigger hierarchical phosphorylation of nearby serines and may play a role in suppressing target mRNA translation. FMRP pS499 Antibody is ideal for researchers interested in neuroscience research.

Gene Name: FMR1

Gen-ID: 24948

NCBI Accession: NP_434691

UniProt: Q80WE1

Pathways: Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development