GRIN2B Antikörper (pSer1166)

Produktnummer ABIN6658155

Hersteller Produkt- Nr.: 600-401-x17

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch GRIN2B in WB und ELISA. Er zeigt eine Reaktivität gegenüber Ratte.

Kurzübersicht für GRIN2B Antikörper (pSer1166) (ABIN6658155)

Target: GRIN2B (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2B (GRIN2B))

Reaktivität: Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GRIN2B Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-GRIN2B Antikörper

Bindungsspezifität: pSer1166

Hersteller Produkt- Nr.: 600-401-x17

Hersteller: Rockland

Verwendungszweck: NMDA NR2B Subunit Phospho S1166 Antibody

Kreuzreaktivität (Details): Anti-Phospho-Ser1166 NMDA Receptor NR2B Subunit Antibody is directed against NMDA protein phosphorylated at S1166.

Aufreinigung: The antibody was prepared from monospecific antiserum by immunoaffinity chromatography using phospho peptide coupled to agarose beads followed by solid phase adsorption(s) against non-phospho peptide and non-specific peptide to remove any unwanted reactivities.

Sterilität: Sterile filtered

Immunogen: Anti-Phospho-Ser1166 NMDA Receptor NR2B Subunit Antibody was produced in rabbits by repeated immunizations with a synthetic phospho-peptide corresponding to amino acid residues surrounding Ser1166 of rat NMDA Receptor NR2B Subunit conjugated to KLH.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

ELISA_Dilution: 1:2,500

Western_Blot_Dilution: 1:250

Kommentare:

Anti-Phospho-Ser1166 NMDA Receptor NR2B Subunit Antibody is tested for Western Blots and is specific for the ~180 kDa NMDAR NR2B subunit phosphorylated at Ser1166. Immunolabeling of the NMDA NR2B subunit band is blocked by the phosphopeptide used as the antigen but not by the corresponding dephosphopeptide. Specific conditions for reactivity should be optimized by the end user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer:

Buffer: 0.01 M HEPES, 0.15 M Sodium Chloride, pH 7.5

Stabilizer: 0.1 mg/mL Bovine Serum Albumin (BSA) - IgG and Protease free, 50 % (v/v) Glycerol

Preservative: None

Konservierungsmittel: Without preservative

Lagerung: -20 °C

Informationen zur Lagerung: Store vial at -20° C prior to opening in undiluted aliquots. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature.

Haltbarkeit: 12 months

Details zu GRIN2B

Target: GRIN2B (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2B (GRIN2B))

Andere Bezeichnung: NMDA NR2B Subunit

Hintergrund:

Synonyms: Glutamate receptor ionotropic, NMDA 2B, GluN2B, Glutamate [NMDA] receptor subunit epsilon-2, N-methyl D-aspartate receptor subtype 2B, NMDAR2B, NR2B

Background: The NMDA receptor (NMDAR) plays an essential role in memory, neuronal development and it has also been implicated in several disorders of the central nervous system including Alzheimer's, epilepsy and ischemic neuronal cell death. Overexpression of the NR2B-subunit of the NMDA Receptor has been associated with increases in learning and memory while aged, memory impaired animals have deficiencies in NR2B expression. Phosphorylation of Ser1166 is thought to play an essential role in memory and neuronal development. NMDA pS1166 Receptor NR2B Subunit Antibody is ideal for researchers interested in neuroscience research.

Gene Name: GRIN2B

Gen-ID: 24410

NCBI Accession: NP_036706

UniProt: Q00960

Pathways: Response to Growth Hormone Stimulus, Synaptic Membrane, Feeding Behaviour, Regulation of long-term Neuronal Synaptic Plasticity