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CGRP Antikörper

CALCA Reaktivität: Ratte ELISA, WB, IHC, IP, FM Wirt: Maus Monoclonal 4901 unconjugated
Produktnummer ABIN6658144
  • Target Alle CGRP (CALCA) Antikörper anzeigen
    CGRP (CALCA) (Calcitonin-Related Polypeptide alpha (CALCA))
    Reaktivität
    • 67
    • 38
    • 12
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Ratte
    Wirt
    • 60
    • 17
    • 6
    • 2
    • 2
    • 1
    Maus
    Klonalität
    • 70
    • 17
    Monoklonal
    Konjugat
    • 58
    • 7
    • 6
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser CGRP Antikörper ist unkonjugiert
    Applikation
    • 54
    • 38
    • 28
    • 13
    • 13
    • 11
    • 10
    • 8
    • 8
    • 7
    • 6
    • 5
    • 3
    • 2
    • 1
    ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Fluorescence Microscopy (FM)
    Kreuzreaktivität
    Human, Ratte (Rattus)
    Aufreinigung
    Anti-CGRP Monoclonal Antibody is directed against rat CGRP protein. The antibody was purified from concentrated tissue culture supernate by Protein G chromatography. This antibody is specific for human and rat CGRP protein. A BLAST analysis was used to suggest cross-reactivity with CGRP from most mammalian sources based on very high homology with the immunizing sequence. Calcitonin Gene Related Peptide antibody also recognizes rat beta-CGRP and human alpha-CGRP (10-fold less sensitivity compared to rat alpha-CGRP).
    Immunogen

    Immunogen: Anti-CGRP Monoclonal Antibody was produced by repeated immunizations with purified rat alpha-CGRP.

    Immunogen Type: Recombinant Protein

    Klon
    4901
    Isotyp
    IgG2a
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  • Applikationshinweise

    Immunohistochemistry Dilution: 1:50-1:100

    Application Note: Anti-Calcitonin Gene Related Peptide antibody is suitable for use in ELISA and ICC. This product is not recommended for use in Western Blotting. Specific conditions for reactivity should be optimized by the end user. Suggested positive controls are dorsal root ganglia, pancreas and gut.

    Immunoprecipitation Dilution: 1:50-1:100

    ELISA Dilution: 1:5,000

    Western Blot Dilution: not recommended

    IF Microscopy Dilution: 1:50-1:100

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer

    Buffer: 0.01 M HEPES, 0.15 M Sodium Chloride, pH 7.5

    Stabilizer: 0.1 mg/mL Bovine Serum Albumin (BSA) - IgG and Protease free, 50 % (v/v) Glycerol

    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Store vial at -20° C prior to opening.  This product is stable at 4° C as an undiluted liquid.  For extended storage, aliquot contents and freeze at -20° C or below.  Avoid cycles of freezing and thawing. Dilute only prior to immediate use.
  • Dhandapani, Arokiaraj, Taberner, Pacifico, Raja, Nocchi, Portulano, Franciosa, Maffei, Hussain, de Castro Reis, Reymond, Perlas, Garcovich, Barth, Johnsson, Lechner, Heppenstall: "Control of mechanical pain hypersensitivity in mice through ligand-targeted photoablation of TrkB-positive sensory neurons." in: Nature communications, Vol. 9, Issue 1, pp. 1640, (2019) (PubMed).

  • Target
    CGRP (CALCA) (Calcitonin-Related Polypeptide alpha (CALCA))
    Andere Bezeichnung
    Calcitonin Gene Related Peptide (CGRP) (CALCA Produkte)
    Synonyme
    CALC1 antikoerper, CGRP antikoerper, CGRP-I antikoerper, CGRP1 antikoerper, CT antikoerper, KC antikoerper, CALC antikoerper, CALCA antikoerper, CALC3 antikoerper, ci-ct antikoerper, calca antikoerper, CA antikoerper, CGRP-1 antikoerper, Calc antikoerper, Calc1 antikoerper, Cgrp antikoerper, Ct antikoerper, Ctn antikoerper, calcitonin antikoerper, CAL6 antikoerper, Cal1 antikoerper, RATCAL6 antikoerper, CGRPI antikoerper, calc antikoerper, cgrp antikoerper, zgc:92886 antikoerper, calcitonin related polypeptide alpha antikoerper, calcitonin related polypeptide beta antikoerper, calcitonin-related polypeptide alpha antikoerper, calcitonin antikoerper, calcitonin/calcitonin-related polypeptide, alpha antikoerper, calcitonin-related polypeptide beta antikoerper, calcitonin gene-related peptide 2 antikoerper, CALCA antikoerper, CALCB antikoerper, ci-ct antikoerper, calca antikoerper, Calca antikoerper, LOC100008771 antikoerper
    Hintergrund

    Synonyms: Alpha-type CGRP, Calcitonin gene-related peptide I

    Background: CGRP antibody recognizes Calcitonin Gene Related Peptide or CGRP which is a 37 amino acid peptide and is the most potent endogenous vasodilator currently known. CGRP is primarily produced in nervous tissue, however, its receptors are expressed throughout the body. CGRP is also strongly implicated in the vasodilatory effect of endogenous cannabinoid anandamide in the brain. This effect was found to be antagonized by capsazepine. CGRP is also currently a major target of research in regards to factors effecting the onset of migraine headaches. CGRP antibodies have been used successfully in immunoneutralization. Anti-CGRP antibody is ideal for investigators involved in Cell Signaling, Neuroscience, Signal Transduction research.

    Gene Name: CALCA

    Gen-ID
    24241
    NCBI Accession
    NP_001029128
    UniProt
    P01256
    Pathways
    Hormone Activity, cAMP Metabolic Process, Myometrial Relaxation and Contraction, Regulation of G-Protein Coupled Receptor Protein Signaling, Skeletal Muscle Fiber Development, Feeding Behaviour
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