GLRA1 Antikörper (N-Term)

Produktnummer ABIN6658137

Hersteller Produkt- Nr.: 600-401-d65

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch GLRA1 in WB und IHC. Er zeigt eine Reaktivität gegenüber Ratte.

Kurzübersicht für GLRA1 Antikörper (N-Term) (ABIN6658137)

Target: GLRA1 (Glycine Receptor, alpha 1 (GLRA1))

Reaktivität: Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GLRA1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-GLRA1 Antikörper

Bindungsspezifität: N-Term

Hersteller Produkt- Nr.: 600-401-d65

Hersteller: Rockland

Verwendungszweck: Glycine Receptor Antibody

Kreuzreaktivität (Details): Anti-Glycine Receptor Antibody is directed against rat Glycine Receptor protein.

Aufreinigung: The antibody was affinity purified from monospecific antiserum by immunoaffinity purification.

Immunogen: Anti-Glycine Receptor Antibody was produced by repeated immunizations with synthetic peptide corresponding to amino acid residues from the N-terminal region.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

Immunohistochemistry_Dilution: 1:1000

Western_Blot_Dilution: 1:1000

Kommentare:

Anti-Glycine Receptor (Rabbit) antibody is tested for use in Western Blotting and IHC. Specific conditions for reactivity should be optimized by the end user. Expect a band of approximately 48 kDa in size corresponding to the alpha 1 and alpha 2 subunits of the glycine receptor in Western Blots of rat spinal cord and brain stem and in cell extracts.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution:

Reconstitution_Buffer: Neutral PBS

Reconstitution_Volume: 50μL

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store vial at 4° C prior to restoration.   For extended storage aliquot contents and freeze at -20° C or below.  Avoid cycles of freezing and thawing.  Centrifuge product if not completely clear after standing at room temperature.  Dilute only prior to immediate use. 

Haltbarkeit: 12 months

Details zu GLRA1

Target: GLRA1 (Glycine Receptor, alpha 1 (GLRA1))

Andere Bezeichnung: Glra1

Hintergrund:

Synonyms: Glycine receptor subunit alpha-1, Glycine receptor 48 kDa subunit, Glycine receptor strychnine-binding subunit

Background: Glycine Receptor Antibody detects Glycine Receptor protein. Glycine is an important inhibitory transmitter in the brainstem and spinal cord. Glycine receptors are members of the ligand-gated ion channel family (LGICs) that mediate rapid chemical neurotransmission. The binding of glycine to its receptor produces a large increase in chloride conductance, which causes membrane hyperpolarization. Glycine receptors are anchored at inhibitory chemical synapses by a cytoplasmic protein, gephyrin. The glycine receptor has been used to great advantage in the identification of the binding sites for alcohol on the LGIC family of proteins. These receptors have also been extremely useful in studies of synaptic clustering of receptors. The glycine receptor may also act in concert with an NMDAR subunit to form an excitatory receptor. Therefore, Glycine receptor antibody is ideal for investigators involved in neurological circuitry and more generally in Neuroscience.

Gene Name: GLRA1

Gen-ID: 25674

NCBI Accession: NP_037265

UniProt: P07727

Pathways: Synaptic Membrane