GRIN2C Antikörper (N-Term)

Produktnummer ABIN6658125

Hersteller Produkt- Nr.: 600-401-d94

Produktdetails anti-GRIN2C Antikörper

Target: GRIN2C (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2c (GRIN2C))

Bindungsspezifität: N-Term

Reaktivität: Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GRIN2C Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Fluorescence Microscopy (FM)

Hersteller Produkt- Nr.: 600-401-d94

Hersteller: Rockland

Verwendungszweck: NMDA R2C Antibody

Kreuzreaktivität (Details): Anti-NMDA R2C antibody is directed against NMDA R2C protein.

Aufreinigung: The antibody was affinity purified from monospecific antiserum by immunoaffinity purification.

Immunogen: Anti-NMDA R2C Antibody was produced by repeated immunizations with a fusion proteins from the N-terminal region of the NR2C subunit.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

Immunoprecipitation_Dilution: 3 μL per 200 μg lysate

Immunohistochemistry_Dilution: 1:1000-2000

IF_Microscopy_Dilution: 1:1000-2000

Western_Blot_Dilution: 1:1000

Other: User Optimized

Kommentare:

Anti-NMDA R2C Antibody is tested for use in Western Blotting and Immunoprecipitation and suitable for IHC and IF. Specific conditions for reactivity should be optimized by the end user. Expect a band of approximately 140 kDa in size corresponding to the NR2C subunit of the NMDA receptor. This antibody also labels the approximately 180 kDa NR2A and NR2B subunits of the NMDA receptor.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution:

Reconstitution_Buffer: Neutral PBS

Reconstitution_Volume: 50μL

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store vial at 4° C prior to restoration.   For extended storage aliquot contents and freeze at -20° C or below.  Avoid cycles of freezing and thawing.  Centrifuge product if not completely clear after standing at room temperature.  Dilute only prior to immediate use. 

Haltbarkeit: 12 months

Referenzen für anti-GRIN2C Antikörper (ABIN6658125)

Yoshikawa, Kan, Shirose, Watanabe, Matsuda, Ito, Kawaguchi: "Free d-Amino Acids in Salivary Gland in Rat." in: Biology, Vol. 11, Issue 3, (2022) (PubMed).

Details zu GRIN2C

Target: GRIN2C (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2c (GRIN2C))

Andere Bezeichnung: NMDA R2C (GRIN2C Produkte)

Hintergrund:

Synonyms: Glutamate [NMDA] receptor subunit epsilon-3, N-methyl D-aspartate receptor subtype 2C, NMDAR2C, NR2C

Background: NMDA R2C Antibody detects NMDA R2C protein. The ion channels activated by glutamate that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR). The NMDAR plays an essential role in memory, neuronal development and it has also been implicated in several disorders of the central nervous system including Alzheimer's, epilepsy and ischemic neuronal cell death. The NMDA receptor is also one of the principal molecular targets for alcohol in the CNS. The NMDAR is also potentiated by protein phosphorylation. The rat NMDAR1 (NR1) was the first subunit of the NMDAR to be cloned. The NR1 protein can form NMDA activated channels when expressed in Xenopus oocytes but the currents in such channels are much smaller than those seen in situ. Channels with more physiological characteristics are produced when the NR1 subunit is combined with one or more of the NMDAR2 (NR2 A-D) subunits. The NR2C subunit of the receptor is thought to influence the NMDAR conductance level. Anti-NMDA R2C Antibody is ideal for investigators involved in Neuroscience, Signal Transduction, and Cell Signaling Research.

Gene Name: GRIN2C

Gen-ID: 24411

UniProt: Q00961

Pathways: Synaptic Membrane