SNCA Antikörper (pSer129)

Produktnummer ABIN6658101

Hersteller Produkt- Nr.: 612-401-c70

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch SNCA in WB und ELISA. Er zeigt eine Reaktivität gegenüber Ratte.

Kurzübersicht für SNCA Antikörper (pSer129) (ABIN6658101)

Target: SNCA (Synuclein, alpha (SNCA))

Reaktivität: Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SNCA Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-SNCA Antikörper

Bindungsspezifität: pSer129

Hersteller Produkt- Nr.: 612-401-c70

Hersteller: Rockland

Verwendungszweck: Alpha Synuclein phospho S129 Antibody

Kreuzreaktivität (Details): Anti-Alpha Synuclein pS129 Antibody is directed against rat Alpha-synuclein phosphorylated at S129.

Aufreinigung: The antibody was prepared from monospecific antiserum by immunoaffinity chromatography using phospho peptide coupled to agarose beads followed by solid phase adsorption(s) against non-phospho peptide and non-specific peptide to remove any unwanted reactivities.

Immunogen: Anti-Alpha Synuclein pS129 Antibody was produced by repeated immunizations with a synthetic phospho peptide corresponding to amino acid residues surrounding Ser129.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

ELISA_Dilution: 1:10,000

Western_Blot_Dilution: 1:1000

Kommentare:

Alpha Synuclein pS129 antibody is tested for use in ELISA, Western Blotting. Specific conditions for reactivity should be optimized by the end user. Expect a band of approximately 15 kDa in size corresponding to the alpha synuclein protein phosphorylated at Ser129 in the appropriate cell lysate or extract.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer:

Buffer: 0.01 M HEPES, 0.15 M Sodium Chloride, pH 7.5

Stabilizer: 0.1 mg/mL Bovine Serum Albumin (BSA) - IgG and Protease free, 50 % (v/v) Glycerol

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store vial at -20° C prior to opening. This product is stable at 4° C as an undiluted liquid. For extended storage, aliquot contents and freeze at -20° C or below. Avoid cycles of freezing and thawing. Dilute only prior to immediate use.

Haltbarkeit: 12 months

Details zu SNCA

Target: SNCA (Synuclein, alpha (SNCA))

Andere Bezeichnung: Alpha Synuclein

Hintergrund:

Synonyms: Non-A beta component of AD amyloid, Non-A4 component of amyloid precursor

Background: Alpha Synuclein pS129 Antibody detects Alpha-synuclein phosphorylated at S129. Alpha-synuclein is a presynaptic neuronal protein that is thought to be involved in the formation of SNARE complexes. Most significantly, aggregated alpha-synuclein is one of the major components found in the Lewy bodies that occur in Parkinson's disease (PD) and other neurodegenerative disorders. Mutation of the alpha-synuclein gene is associated with familial forms of PD. Recent evidence suggests that phosphorylation of alpha-synuclein at Ser129 plays a role in the formation of inclusions in PD. Anti-Alpha-synuclein pS129 antibody is ideal for investigators involved in Cell Signaling, Neuroscience, Signal Transduction research.

Gene Name: SNCA

Gen-ID: 29219

NCBI Accession: NP_062042

UniProt: P37377

Pathways: Synaptic Membrane, Regulation of G-Protein Coupled Receptor Protein Signaling, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Platelet-derived growth Factor Receptor Signaling, Negative Regulation of Transporter Activity, Regulation of long-term Neuronal Synaptic Plasticity