MFN2 Antikörper (AA 370-600)

Produktnummer ABIN6657970

Hersteller Produkt- Nr.: 200-301-w71

Der Maus Monoklonal Anti-MFN2-Antikörper wurde für WB, IHC und ELISA validiert. Er ist geeignet, MFN2 in Proben von Maus zu detektieren.

Kurzübersicht für MFN2 Antikörper (AA 370-600) (ABIN6657970)

Target: MFN2 (Mitofusin 2 (MFN2))

Reaktivität: Maus

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser MFN2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Klon: S153-5

Produktdetails anti-MFN2 Antikörper

Bindungsspezifität: AA 370-600

Hersteller Produkt- Nr.: 200-301-w71

Hersteller: Rockland

Verwendungszweck: Mitofusin 2 Antibody

Kreuzreaktivität (Details): BLAST analysis suggests that it is 97 % identical to rat, 92 % identical to human and ~55 % identical to Mitofusin 1.

Aufreinigung: Anti-Mitofusin 2 Antibody was purified from concentrated tissue culture supernate by Protein G chromatography.

Sterilität: Sterile filtered

Immunogen: Anti-Mitofusin 2 Antibody was produced by repeated immunization of mice with a fusion protein containing amino acids 370-600 of mouse Mitofusin 2.

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise:

ELISA_Dilution: 1:10,000

Immunohistochemistry_Dilution: User Optimized

Western_Blot_Dilution: 1:1000

Other: ICC/IF: 1:100

Kommentare:

Anti-Mitofusin 2 Antibody is tested for Western Blots, Immunohistochemistry and Immunocytochemistry. Expect a band approximately ~90kDa on specific lysates or tissues. Does not cross react with Mitofusin 1. Specific conditions for reactivity should be optimized by the end user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer:

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Stabilizer: 50 % (v/v) Glycerol

Preservative: 0.1 % (w/v) Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

Haltbarkeit: 12 months

Details zu MFN2

Target: MFN2 (Mitofusin 2 (MFN2))

Andere Bezeichnung: Mitofusin 2

Hintergrund:

Synonyms: CMT2A, CMT2A2, CPRP 1, CPRP1, Fzo, HSG, hyperplasia suppressor gene, Hypertension related protein 1, KIAA0214, MARF, MFN 2, Mfn2, Mitochondrial assembly regulatory factor, Mitofusin-2, Mitofusin2, Transmembrane GTPase MFN2

Background: Mitofusin-2 (Mfn2) is a membrane protein of the mitochondria and is important in mitochondrial fusion in mammalian cells. Mfn2 activity has also been implicated in mitochondrial metabolism and the loss of Mfn2 may be the reason for certain metabolic modifications that are seen in individuals with obesity. Mfn2 has been associated with maintaining the membrane potential of the mitochondria. Mfn2 has been shown to hinder mitochondrial antiviral signaling by inhibiting production of type 1 interferons. Mfn2 is a p53-inducible target and involved in cell proliferation, apoptosis promotion and tumor suppression. Anti-Mitofusin-2 is ideal for research in Metabolic Processes and Hemostasis.

Gene Name: Mitofusin-2

Gen-ID: 170731

UniProt: Q80U63

Pathways: Skeletal Muscle Fiber Development