LOX Antikörper

Produktnummer ABIN6655735

Hersteller Produkt- Nr.: 100-401-h91

Der Kaninchen Polyklonal Anti-LOX-Antikörper wurde für WB, IHC, IF, IP und FM validiert. Er ist geeignet, LOX in Proben von Human zu detektieren.

Kurzübersicht für LOX Antikörper (ABIN6655735)

Target: LOX (Lysyl Oxidase (LOX))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser LOX Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP), Fluorescence Microscopy (FM)

Produktdetails anti-LOX Antikörper

Hersteller Produkt- Nr.: 100-401-h91

Hersteller: Rockland

Verwendungszweck: Lysyl Oxidase Antibody

Kreuzreaktivität (Details): A BLAST analysis was used to suggest cross-reactivity with Anti-Lysyl Oxidase from human, bovine, chimpanzee, mouse and rat 100 % homology with the immunizing sequence.

Aufreinigung: Anti-Lysyl Oxidase Antibody is crude rabbit sera.

Immunogen: Lysyl Oxidase Antibody was produced from whole rabbit serum prepared by repeated immunizations with the human protein Lysyl Oxidase at an internal amino acid sequence.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

Immunoprecipitation_Dilution: User Optimized

Immunohistochemistry_Dilution: 1:100

IF_Microscopy_Dilution: User Optimized

Western_Blot_Dilution: 1:250-1:1000

Kommentare:

Anti-Lysyl Oxidase antibody has been tested in WB, ICC/IF, IHC-F, IHC-P, IP. Expect a band approximately 31kDa on specific lysates. Specific conditions for reactivity should be optimized by the end user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Optional[Buffer]: 50 % (v/v) Glycerol ,0.05 % (w/v) Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

Haltbarkeit: 12 months

Details zu LOX

Target: LOX (Lysyl Oxidase (LOX))

Andere Bezeichnung: Lysyl Oxidase

Hintergrund:

Synonyms: Lysyl oxidase, LOX, Protein-lysine-6 oxidase

Background: Anti-Lysyl Oxidase antibody detects human Lysyl Oxidase. Lysyl Oxidase (LOX) belongs to a heterogeneous family of enzymes that oxidize primary amine substrates to reactive aldehydes. It plays a vital role in the formation and repair of ECM. Localized both in the cytosol and nucleus, it catalyzes the oxidation and deamination of epsilon-NH2 group of lysine and hydroxylysine residues to alpha-aminoadipic-delta-semialdehyde. This is the first step that initiates the covalent cross-linking of collagen and tropoelastin resulting in the formation of insoluble collagen and elastic fibers in the extracellular matrix. LOX is a multifunctional enzyme having diverse biological functions such as developmental regulation, tumor suppression, cell motility and cellular senescence. Deficiency of LOX is seen in certain carcinomas and 3X-linked recessive human connective tissue disorders-Cutis Laxa. Anti-Lysyl Oxidase antibody is ideal for investigators involved in cytokines and growth factors.

Gene Name: LOX

Gen-ID: 4015

NCBI Accession: NP_002308

UniProt: P28300

Pathways: SARS-CoV-2 Protein Interaktom