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THRB Antikörper (N-Term)

Dieses Maus Monoklonal-Antikörper erkennt spezifisch THRB in WB. Er zeigt eine Reaktivität gegenüber Human und wurde in 2+ Publikationen erwähnt.
Rockland
Produktnummer ABIN6655581
Hersteller Produkt- Nr.: 209-301-a96

Kurzübersicht für THRB Antikörper (N-Term) (ABIN6655581)

Target

Alle THRB Antikörper anzeigen
THRB (Thyroid Hormone Receptor, beta (THRB))

Reaktivität

  • 59
  • 32
  • 32
  • 6
  • 5
  • 5
  • 5
  • 4
  • 4
  • 4
  • 3
  • 3
  • 1
Human

Wirt

  • 58
  • 6
  • 1
Maus

Klonalität

  • 59
  • 6
Monoklonal

Konjugat

  • 40
  • 3
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser THRB Antikörper ist unkonjugiert

Applikation

  • 55
  • 23
  • 19
  • 15
  • 13
  • 13
  • 7
  • 5
  • 4
  • 4
  • 4
  • 2
  • 1
Western Blotting (WB)

Klon

2386
  • Bindungsspezifität

    • 16
    • 8
    • 7
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term

    Hersteller Produkt- Nr.

    209-301-a96

    Hersteller

    Rockland

    Verwendungszweck

    Thyroid Hormone Receptor beta Antibody

    Kreuzreaktivität (Details)

    Thyroid Hormone Receptor beta antibody is purified by Protein G chromatography from cell culture supernatant.

    Aufreinigung

    Anti-Thyroid Hormone Receptor beta antibody is directed against human TRβ.

    Immunogen

    Anti-Thyroid Hormone Receptor beta monoclonal antibody was produced in mouse by repeated immunizations with synthetic peptide corresponding to amino acid residues from the N-terminal region of Thyroid Hormone Receptor beta.

    Isotyp

    IgG1
  • Applikationshinweise

    Optional[Neutralization_Dilution]: 1:1000

    Kommentare

    Suggested Applications: IHC
    Anti-Thyroid Hormone Receptor beta (Mouse) antibody is tested for use in Western Blotting. Expect a band of approximately 55 kDa corresponding to TR-β proteins in the appropriate cell lysate or extract. Researchers should determine optimal titers for applications that are not stated below.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Buffer

    Buffer: 0.01 M HEPES, 0.15 M Sodium Chloride, pH 7.5

    Stabilizer: 0.1 mg/mL Bovine Serum Albumin (BSA) - IgG and Protease free, 50 % (v/v) Glycerol

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Store vial at -20° C prior to opening.  This product is stable at 4° C as an undiluted liquid.  For extended storage, aliquot contents and freeze at -20° C or below.  Avoid cycles of freezing and thawing. Dilute only prior to immediate use.

    Haltbarkeit

    12 months
  • Aksoy, Pencik, Hartenbach, Moazzami, Schlederer, Balber, Varady, Philippe, Baltzer, Mazumder, Whitchurch, Roberts, Haitel, Herac, Susani, Mitterhauser, Marculescu, Stangl-Kremser, Hassler, Kramer, Shariat, Turner, Tichy, Oppelt, Pospisilova, Hartenbach, T: "Thyroid and androgen receptor signaling are antagonized by μ-Crystallin in prostate cancer." in: International journal of cancer, Vol. 148, Issue 3, pp. 731-747, (2021) (PubMed).

    Schnoell, Kotowski, Jank, Stoiber, Gurnhofer, Schlederer, Heiduschka, Kenner, Kadletz-Wanke: "Prognostic Relevance of Thyroid-Hormone-Associated Proteins in Adenoid Cystic Carcinoma of the Head and Neck." in: Journal of personalized medicine, Vol. 11, Issue 12, (2021) (PubMed).

  • Target

    THRB (Thyroid Hormone Receptor, beta (THRB))

    Andere Bezeichnung

    Thyroid Hormone Receptor beta

    Hintergrund

    Synonyms: mouse anti-Thyroid Hormone Receptor beta Antibody, mouse anti-Thrb antibody, Nuclear receptor subfamily 1 group A member 2, c-erbA-2, c-erbA-beta

    Background: Thyroid Hormone Receptor beta antibody detects Thyroid Hormone Receptor beta. Thyroid hormones are essential for development of the central nervous system and deficits in these hormones during development affects such cognitive functions as learning and memory. Thyroid hormones exert their physiological role mainly through binding to specific nuclear receptors including the predominant isoforms of thyroid hormone receptors TRα1, TRα2, TRβ1 and TRβ2. TRα1, TRβ1 and TRβ2 bind T3 with high affinity and also bind to thyroid hormone response elements (TREs) on chromatin to regulate the transcriptional processes in several target tissues, including adult rat brain. Thyroid Hormone Receptor beta antibody is ideal for investigators involved in Cell Signaling, Neuroscience, Signal Transduction research.

    Gene Name: THRB

    Gen-ID

    7068

    NCBI Accession

    NP_000452

    UniProt

    P10828

    Pathways

    Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Sensory Perception of Sound
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