S1PR4 Antikörper (N-Term)

Produktnummer ABIN6655347

Hersteller Produkt- Nr.: 600-401-i18

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch S1PR4 in WB, IF, IHC und FM. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für S1PR4 Antikörper (N-Term) (ABIN6655347)

Target: S1PR4 (Sphingosine-1-Phosphate Receptor 4 (S1PR4))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser S1PR4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (IHC), Fluorescence Microscopy (FM)

Produktdetails anti-S1PR4 Antikörper

Bindungsspezifität: N-Term

Hersteller Produkt- Nr.: 600-401-i18

Hersteller: Rockland

Verwendungszweck: Edg6 Antibody

Kreuzreaktivität (Details): A BLAST analysis was used to suggest cross-reactivity with Edg6 from human, mouse and rat based on 100 % homology with the immunizing sequence.

Aufreinigung: Anti-Edg6 Antibody was purified by affinity chromatography.

Immunogen: Edg6 Antibody was produced from whole rabbit serum prepared by repeated immunizations with the n-terminus amino acid portion of human Edg6 protein.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

IF_Microscopy_Dilution: 5 μg/mL

Western_Blot_Dilution: 3.0-5.0 μg/mL

Other: ICC: 5 μg/mL

Kommentare:

Anti-Edg6 is tested for use in WB, ICC/IF, IHC, and IHC-P. Expect a band approximately 35kDa on specific lysates. Specific conditions for reactivity should be optimized by the end user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer:

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Stabilizer: 0.05 % BSA

Preservative: 0.05 % (w/v) Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

Haltbarkeit: 12 months

Details zu S1PR4

Target: S1PR4 (Sphingosine-1-Phosphate Receptor 4 (S1PR4))

Andere Bezeichnung: Edg6

Hintergrund:

Synonyms: EDG6, Sphingosine 1-phosphate receptor 4, S1P receptor 4, S1P4, Endothelial differentiation G-protein coupled receptor 6, Sphingosine 1-phosphate receptor Edg-6, S1P receptor Edg-6

Background: Anti-Sphingolipid Receptor Edg6 S1P4 detects human and mouse Sphingolipid Receptor Edg6 S1P4. Edg6 is a recently cloned member of the endothelial differentiation gene (EDG) G protein-coupled receptor family. It is a receptor for the lysosphingolipid sphingosine 1-phosphate (S1P), which are structurally related lysophospholipid mediators. Binding of SPP to Edg6 activates Erk, leading to the activation of the transcription factor Elk1 and thus the mitogen-activated protein kinase (MAPK) signal transduction pathway. The protein also acts as a receptor for a lipid-derived ligand. Edg6 plays an essential role in lymphocyte cell signaling. The protein is specifically expressed in fetal and adult lymphoid and hematopoietic tissue as well as in lung. Human Edg6 gene is intronless and is mapped to chromosome 19p13.3 at the D19S120 marker. Anti-Sphingolipid Receptor Edg6 S1P4 antibody is ideal for investigators involved in neurobiology.

Gene Name: S1PR4

UniProt: O95977