PML Antikörper

Produktnummer ABIN6655213

Hersteller Produkt- Nr.: 600-401-x44

Der Kaninchen Polyklonal Anti-PML-Antikörper wurde für WB und ELISA validiert. Er ist geeignet, PML in Proben von Human zu detektieren.

Kurzübersicht für PML Antikörper (ABIN6655213)

Target: PML (Promyelocytic Leukemia (PML))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PML Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-PML Antikörper

Hersteller Produkt- Nr.: 600-401-x44

Hersteller: Rockland

Verwendungszweck: PML Antibody

Kreuzreaktivität (Details): Cross reactivity with other species was not tested.

Aufreinigung: Anti-PML Antibody was purified by affinity purification.

Sterilität: Sterile filtered

Immunogen: Anti-PML Antibody was produced in rabbits by repeated immunizations with three different synthetic peptides from human PML.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

ELISA_Dilution: 1:100 - 1:200

Western_Blot_Dilution: 1:750

Kommentare:

Anti-PML Antibody is tested for ELISA and Western Blots. Specific conditions for reactivity should be optimized by the end user. Expect a band approximately 115 and 60 kDa in the appropriate cell lysate or extract.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer:

Buffer: 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride, pH 7.2

Stabilizer: None

Preservative: 0.05 % (w/v) Sodium Azide and 0.05 % ProClin 300

Konservierungsmittel: ProClin, Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide and ProClin: POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

Haltbarkeit: 12 months

Details zu PML

Target: PML (Promyelocytic Leukemia (PML))

Andere Bezeichnung: PML

Hintergrund:

Synonyms: Protein PML Promyelocytic leukemia protein, RING finger protein 71, Tripartite motif-containing protein 19, MYL, PP8675, RNF71, TRIM19

Background: PML is a transcription factor and tumor supressor which belongs to the tripartite motif (TRIM) family. This motif contains three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. PML regulates the response of p53 to oncogenic signals. It is often involved in a chromosomal translocation between chromosomes 15 and 17 which results in a PML/RARalpha fusion protein and is associated with most cases of acute promyelocytic leukemia. Anti-PML Antibody is ideal for research in Gene Expression, Cell Cycle Control and Cancer.

Gene Name: PML

Gen-ID: 5371

NCBI Accession: NP_002666

UniProt: P29590

Pathways: p53 Signalweg, Retinoic Acid Receptor Signaling Pathway, Maintenance of Protein Location, Positive Regulation of Endopeptidase Activity, Protein targeting to Nucleus