ABCA4 Antikörper

Produktnummer ABIN6655047

Hersteller Produkt- Nr.: 200-301-d05

Dieses Maus Monoklonal-Antikörper erkennt spezifisch ABCA4 in WB, IHC und ELISA. Er zeigt eine Reaktivität gegenüber Rind (Kuh) und wurde in 1 Publikation erwähnt.

Kurzübersicht für ABCA4 Antikörper (ABIN6655047)

Target: ABCA4 (ATP-Binding Cassette, Sub-Family A (ABC1), Member 4 (ABCA4))

Reaktivität: Rind (Kuh)

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser ABCA4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Klon: 3F4

Produktdetails anti-ABCA4 Antikörper

Hersteller Produkt- Nr.: 200-301-d05

Hersteller: Rockland

Verwendungszweck: ABCA4 Rim Protein Antibody

Kreuzreaktivität (Details): Anti-ABCA4 antibody is directed against bovine ABCA4 Rim Protein.

Aufreinigung: The antibody was Protein G purified from culture supernatant.

Immunogen: Anti-ABCA4 antibody was produced by repeated immunizations with 220-kDa (full length) partially purified native bovine disc rim protein.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

ELISA_Dilution: 1:10,000

Immunohistochemistry_Dilution: 1:100

Western_Blot_Dilution: 1:1000

Kommentare:

Suggested Applications: IF
Anti-ABCA4 antibody has been tested by western blot and IHC and is suitable for use in ELISA. Specific conditions should be optimized by the end user. Expect a band of ~220kDa in size corresponding to ABCA4 proteins in the appropriate cell lysate or extract.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer:

Buffer: 0.01 M HEPES, 0.15 M Sodium Chloride, pH 7.5

Stabilizer: 0.1 mg/mL Bovine Serum Albumin (BSA) - IgG and Protease free, 50 % (v/v) Glycerol

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store vial at -20° C prior to opening.  This product is stable at 4° C as an undiluted liquid.  For extended storage, aliquot contents and freeze at -20° C or below.  Avoid cycles of freezing and thawing. Dilute only prior to immediate use.

Haltbarkeit: 12 months

Referenzen für anti-ABCA4 Antikörper (ABIN6655047)

Cowan, Renner, De Gennaro, Gross-Scherf, Goldblum, Hou, Munz, Rodrigues, Krol, Szikra, Cuttat, Waldt, Papasaikas, Diggelmann, Patino-Alvarez, Galliker, Spirig, Pavlinic, Gerber-Hollbach, Schuierer, Srdanovic, Balogh, Panero, Kusnyerik, Szabo, Stadler, Org: "Cell Types of the Human Retina and Its Organoids at Single-Cell Resolution." in: Cell, Vol. 182, Issue 6, pp. 1623-1640.e34, (2021) (PubMed).

Details zu ABCA4

Target: ABCA4 (ATP-Binding Cassette, Sub-Family A (ABC1), Member 4 (ABCA4))

Andere Bezeichnung: ABCA4 Rim Protein

Hintergrund:

Synonyms: Retinal-specific ATP-binding cassette transporter, ATP-binding cassette sub-family A member 4, RIM ABC transporter

Background: ABCA4 antibody detects ABCA4 (ATP-binding cassette, sub-family A (ABC1), member 4, Rim Protein) a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABCA4 is a retina-specific ABC transporter with N-retinylidene-PE as a substrate. It is expressed exclusively in retina photoreceptor cells, indicating the gene product mediates transport of an essential molecule across the photoreceptor cell membrane. Mutations in this gene are found in patients diagnosed with Stargardt disease and are associated with retinitis pigmentosa-19 and age-related macular degeneration. Defects in ABCA4 are the cause of Stargardt disease type 1 (STGD1). STGD is one of the most frequent causes of macular degeneration in childhood. Defects in ABCA4 are also known to cause fundus flavimaculatus (FFM), age-related macular degeneration type 2 (ARMD2) and cone-rod dystrophy type 3 (CORD3). Anti-ABCA4 antibody is ideal for investigators involved in Cell Signaling, Neuroscience, Signal Transduction research.

Gene Name: ABCA4

Gen-ID: 11304

NCBI Accession: NP_776646

UniProt: O35600