CA9 Antikörper

Produktnummer ABIN6654742

Der Kaninchen Monoklonal Anti-CA9-Antikörper wurde für IHC (p) validiert. Er ist geeignet, CA9 in Proben von Human zu detektieren.

Kurzübersicht für CA9 Antikörper (ABIN6654742)

Target: CA9 (Carbonic Anhydrase IX (CA9))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser CA9 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: CA9-2993R

Produktdetails anti-CA9 Antikörper

Aufreinigung: Purified

Reinheit: Protein A affinity chromatography

Immunogen: Recombinant human protein was used as the immunogen for this recombinant Carbonic Anhydrase 9 antibody.

Isotyp: IgG kappa

Anwendungsinformationen

Applikationshinweise: The optimal dilution of the recombinant Carbonic Anhydrase 9 antibody for each application should be determined by the researcher.

1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.\. Immunohistochemistry (FFPE): 0.5-1 μg/mL for 30 min at RT,Prediluted IHC only format: incubate for 30 min at RT (1)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Konservierungsmittel: Azide free

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store the recombinant Carbonic Anhydrase 9 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).

Details zu CA9

Target: CA9 (Carbonic Anhydrase IX (CA9))

Andere Bezeichnung: CA9 / Carbonic Anhydrase IX

Hintergrund: Recognizes a glycoprotein of ~200 kDa, identified as carbonic anhydrase IX (CAIX/gp200). Its epitope resides in the carbohydrate domain of gp200. It shows no significant cross-reactivity with other carbohydrate determinants, such as the Lewis blood group antigens, epithelial membrane antigen, HMFG, and AB blood group antigens. In normal kidney, gp200 is localized along the brush border of the pars convoluta and pars recta segments of the proximal tubule, as well as focally along the luminal surface of Bowman's capsule adjoining the outgoing proximal tubule. Reportedly, gp200 is expressed by 93 % of primary and 84 % of metastatic renal cell carcinomas. This MAb may be useful in the investigations of carcinomas of proximal nephrogenic differentiation especially those showing tubular differentiation.