BAP1 Antikörper (AA 191-326)

Produktnummer ABIN6654721

Der Maus Monoklonal anti-BAP1 Antikörper wird verwendet zum Nachweis von BAP1 in Proben von Human. Er wurde validiert für ELISA.

Kurzübersicht für BAP1 Antikörper (AA 191-326) (ABIN6654721)

Target: BAP1 (BRCA1 Associated Protein-1 (Ubiquitin Carboxy-terminal Hydrolase) (BAP1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser BAP1 Antikörper ist unkonjugiert

Applikation: ELISA

Klon: BAP1-2431

Produktdetails anti-BAP1 Antikörper

Bindungsspezifität: AA 191-326

Verwendungszweck: BAP1 Antibody / BRCA1-Associated Protein 1

Aufreinigung: Protein G affinity chromatography

Immunogen: A portion of amino acids 191-326 from the human protein was used as the immunogen for the BAP1 antibody.

Isotyp: IgG2c, kappa

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the BAP1 antibody to be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store the BAP1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Details zu BAP1

Target: BAP1 (BRCA1 Associated Protein-1 (Ubiquitin Carboxy-terminal Hydrolase) (BAP1))

Andere Bezeichnung: BAP1

Hintergrund: The BAP1 gene belongs to the ubiquitin C-terminal hydrolase subfamily of de-ubiquitination enzymes that are involved in the removal of ubiquitin from proteins. The encoded enzyme binds to the breast cancer type 1 susceptibility protein (BRCA1) via the RING finger domain of the latter and acts as a tumor suppressor. In addition, the enzyme may be involved in regulation of transcription, regulation of cell cycle and growth, response to DNA damage and chromatin dynamics. Germ line mutations in this gene may be associated with tumor predisposition syndrome (TPDS), which involves increased risk of cancers including malignant mesothelioma, Uveal melanoma and cutaneous melanoma.

UniProt: Q92560